Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice
Objective: Scientificstudies have shown that Vitis vinifera (V. vinifera) contains flavonoids and stillbenoids. Flavonoids are well known to possess anxiolytic activities. In view of the idea that flavonoids present in V. vinifera could be useful in anxiety, we evaluated anxiolytic-like activity of...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2016-04-01
|
| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_5818_88b40c7551236d88a3c4373f17972e4d.pdf |
| _version_ | 1818024763372601344 |
|---|---|
| author | Muhammad Aslam Nuzhat Sultana |
| author_facet | Muhammad Aslam Nuzhat Sultana |
| author_sort | Muhammad Aslam |
| collection | DOAJ |
| description | Objective: Scientificstudies have shown that Vitis vinifera (V. vinifera) contains flavonoids and stillbenoids. Flavonoids are well known to possess anxiolytic activities. In view of the idea that flavonoids present in V. vinifera could be useful in anxiety, we evaluated anxiolytic-like activity of V. vinifera juice (VVJ). Materials and Methods: Light/dark box and the open field test were used to assess the anxiolytic potential of V. vinifera juice (VVJ). The juice was given orally by gavage at the dose of 4 and 8 mL/kg body weight. Diazepam (1 mg/kg i.p.) was used as the standard drug. Results: It was observed that the juice produced significant and dose dependent increase in the time spent in light cubicle (p |
| first_indexed | 2024-12-10T04:05:23Z |
| format | Article |
| id | doaj.art-d8c45f9229f6485a93a66f414004c1b0 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-10T04:05:23Z |
| publishDate | 2016-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-d8c45f9229f6485a93a66f414004c1b02022-12-22T02:02:52ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492016-04-01633443505818Evaluation of anxiolytic-like activity of Vitis vinifera juice in miceMuhammad Aslam0Nuzhat Sultana1Department of Pharmacology, Faculty of Pharmacy, University of Karachi-75270, PakistanDepartment of Pharmacology, Faculty of Pharmacy, University of Karachi-75270, PakistanObjective: Scientificstudies have shown that Vitis vinifera (V. vinifera) contains flavonoids and stillbenoids. Flavonoids are well known to possess anxiolytic activities. In view of the idea that flavonoids present in V. vinifera could be useful in anxiety, we evaluated anxiolytic-like activity of V. vinifera juice (VVJ). Materials and Methods: Light/dark box and the open field test were used to assess the anxiolytic potential of V. vinifera juice (VVJ). The juice was given orally by gavage at the dose of 4 and 8 mL/kg body weight. Diazepam (1 mg/kg i.p.) was used as the standard drug. Results: It was observed that the juice produced significant and dose dependent increase in the time spent in light cubicle (phttp://ajp.mums.ac.ir/article_5818_88b40c7551236d88a3c4373f17972e4d.pdfVitis viniferaAnxietyFlavonoidsOpen field testThe light/dark box |
| spellingShingle | Muhammad Aslam Nuzhat Sultana Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice Avicenna Journal of Phytomedicine Vitis vinifera Anxiety Flavonoids Open field test The light/dark box |
| title | Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice |
| title_full | Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice |
| title_fullStr | Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice |
| title_full_unstemmed | Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice |
| title_short | Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice |
| title_sort | evaluation of anxiolytic like activity of vitis vinifera juice in mice |
| topic | Vitis vinifera Anxiety Flavonoids Open field test The light/dark box |
| url | http://ajp.mums.ac.ir/article_5818_88b40c7551236d88a3c4373f17972e4d.pdf |
| work_keys_str_mv | AT muhammadaslam evaluationofanxiolyticlikeactivityofvitisviniferajuiceinmice AT nuzhatsultana evaluationofanxiolyticlikeactivityofvitisviniferajuiceinmice |