Impact of mixing insufficiencies on L-phenylalanine production with an Escherichia coli reporter strain in a novel two-compartment bioreactor

Impact of mixing insufficiencies on L-phenylalanine production with an Escherichia coli reporter strain in a novel two-compartment bioreactor

Abstract Background The omnipresence of population heterogeneity in industrial bioprocesses originates from prevailing dynamic bioprocess conditions, which promote differences in the expression of cellular characteristics. Despite the awareness, the concrete consequences of this phenomenon remain po...

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Bibliographic Details
Main Authors: Manh Dat Hoang, Ingmar Polte, Lukas Frantzmann, Nikolas von den Eichen, Anna-Lena Heins, Dirk Weuster-Botz
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Microbial Cell Factories
Subjects:
Escherichia coli
Reporter strains
Amino acid production
Two-compartment bioreactor
Coiled flow inverter
Population heterogeneity
Online Access:https://doi.org/10.1186/s12934-023-02165-4

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