Higher dietary acid load is associated with an increased risk of metabolic syndrome
Abstract There have been inconsistent reports regarding the association between dietary acid load and Metabolic Syndrome (MetS). We aimed to investigate the association between dietary acid load and MetS in an Iranian adult population. In this cross-sectional study, 1945 participants aged 35–65 year...
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| Format: | Article |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48429-2 |
| _version_ | 1827581676867289088 |
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| author | Najmeh Seifi Hamidreza Rahimi Glareh Koochakpoor Amin Zarei Reza Assaran Darban Gordon A. Ferns Majid Ghayour-Mobarhan |
| author_facet | Najmeh Seifi Hamidreza Rahimi Glareh Koochakpoor Amin Zarei Reza Assaran Darban Gordon A. Ferns Majid Ghayour-Mobarhan |
| author_sort | Najmeh Seifi |
| collection | DOAJ |
| description | Abstract There have been inconsistent reports regarding the association between dietary acid load and Metabolic Syndrome (MetS). We aimed to investigate the association between dietary acid load and MetS in an Iranian adult population. In this cross-sectional study, 1945 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acidity was assessed as the net endogenous acid production (NEAP), potential renal acid load (PRAL), and dietary acid load (DAL). To define MetS, the International Diabetes Federation (IDF) criteria were used. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and MetS. Participants' mean age and BMI were 47.13 ± 7.78 years and 27.57 ± 4.48 kg/m2, respectively. Around 57% of the population was female. Overall, 31.9% had MetS. According to the full-adjusted model, there was a significant association between higher quartiles of PRAL, NEAP, and DAL and MetS (Q4 PRAL; OR (95%CI) 1.42(1.05–1.91), Q4 NEAP; OR (95%CI) 1.48(1.11–1.98), Q4 DAL; OR (95%CI) 1.44(1.05–1.91)). This study showed a significant positive association between different dietary acid load indicators (PRAL, NEAP, and DAL) and odds of MetS among Iranian adults. |
| first_indexed | 2024-03-08T22:39:49Z |
| format | Article |
| id | doaj.art-d8c68d38a4b642c8b64eac6669758a1a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:39:49Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d8c68d38a4b642c8b64eac6669758a1a2023-12-17T12:15:28ZengNature PortfolioScientific Reports2045-23222023-12-011311710.1038/s41598-023-48429-2Higher dietary acid load is associated with an increased risk of metabolic syndromeNajmeh Seifi0Hamidreza Rahimi1Glareh Koochakpoor2Amin Zarei3Reza Assaran Darban4Gordon A. Ferns5Majid Ghayour-Mobarhan6International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesSchool of Nursing and Allied Medical Sciences, Maragheh University of Medical SciencesDepartment of Biology, Mashhad Branch, Islamic Azad UniversityDepartment of Biology, Mashhad Branch, Islamic Azad UniversityDivision of Medical Education, Brighton & Sussex Medical SchoolInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical SciencesAbstract There have been inconsistent reports regarding the association between dietary acid load and Metabolic Syndrome (MetS). We aimed to investigate the association between dietary acid load and MetS in an Iranian adult population. In this cross-sectional study, 1945 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acidity was assessed as the net endogenous acid production (NEAP), potential renal acid load (PRAL), and dietary acid load (DAL). To define MetS, the International Diabetes Federation (IDF) criteria were used. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and MetS. Participants' mean age and BMI were 47.13 ± 7.78 years and 27.57 ± 4.48 kg/m2, respectively. Around 57% of the population was female. Overall, 31.9% had MetS. According to the full-adjusted model, there was a significant association between higher quartiles of PRAL, NEAP, and DAL and MetS (Q4 PRAL; OR (95%CI) 1.42(1.05–1.91), Q4 NEAP; OR (95%CI) 1.48(1.11–1.98), Q4 DAL; OR (95%CI) 1.44(1.05–1.91)). This study showed a significant positive association between different dietary acid load indicators (PRAL, NEAP, and DAL) and odds of MetS among Iranian adults.https://doi.org/10.1038/s41598-023-48429-2 |
| spellingShingle | Najmeh Seifi Hamidreza Rahimi Glareh Koochakpoor Amin Zarei Reza Assaran Darban Gordon A. Ferns Majid Ghayour-Mobarhan Higher dietary acid load is associated with an increased risk of metabolic syndrome Scientific Reports |
| title | Higher dietary acid load is associated with an increased risk of metabolic syndrome |
| title_full | Higher dietary acid load is associated with an increased risk of metabolic syndrome |
| title_fullStr | Higher dietary acid load is associated with an increased risk of metabolic syndrome |
| title_full_unstemmed | Higher dietary acid load is associated with an increased risk of metabolic syndrome |
| title_short | Higher dietary acid load is associated with an increased risk of metabolic syndrome |
| title_sort | higher dietary acid load is associated with an increased risk of metabolic syndrome |
| url | https://doi.org/10.1038/s41598-023-48429-2 |
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