Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>)
<p>Abstract</p> <p>Background</p> <p>Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative o...
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://www.biomedcentral.com/1746-6148/8/97 |
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| author | Aristizabal-Arbelaez Mónica Mejía-Restrepo Julian Montoya-Flórez Mauricio Grandi Fabrizio Pedraza-Ordóñez Francisco |
| author_facet | Aristizabal-Arbelaez Mónica Mejía-Restrepo Julian Montoya-Flórez Mauricio Grandi Fabrizio Pedraza-Ordóñez Francisco |
| author_sort | Aristizabal-Arbelaez Mónica |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.</p> <p>Case presentation</p> <p>The present study is related to a case of an intestinal leiomyoma in a black crested macaque (<it>Macaca nigra</it>), kept on captivity by Matecaña Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to <it>tunica muscularis,</it> resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.</p> <p>Conclusion</p> <p>Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease.</p> |
| first_indexed | 2024-12-11T17:33:35Z |
| format | Article |
| id | doaj.art-d8c6daaf606943c5807ff011554826c0 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-11T17:33:35Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-d8c6daaf606943c5807ff011554826c02022-12-22T00:56:45ZengBMCBMC Veterinary Research1746-61482012-06-01819710.1186/1746-6148-8-97Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>)Aristizabal-Arbelaez MónicaMejía-Restrepo JulianMontoya-Flórez MauricioGrandi FabrizioPedraza-Ordóñez Francisco<p>Abstract</p> <p>Background</p> <p>Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.</p> <p>Case presentation</p> <p>The present study is related to a case of an intestinal leiomyoma in a black crested macaque (<it>Macaca nigra</it>), kept on captivity by Matecaña Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to <it>tunica muscularis,</it> resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.</p> <p>Conclusion</p> <p>Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease.</p>http://www.biomedcentral.com/1746-6148/8/97NeoplasmSmall bowel<it>Macaca</it>MonkeyLeiomyomaIntestine |
| spellingShingle | Aristizabal-Arbelaez Mónica Mejía-Restrepo Julian Montoya-Flórez Mauricio Grandi Fabrizio Pedraza-Ordóñez Francisco Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>) BMC Veterinary Research Neoplasm Small bowel <it>Macaca</it> Monkey Leiomyoma Intestine |
| title | Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>) |
| title_full | Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>) |
| title_fullStr | Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>) |
| title_full_unstemmed | Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>) |
| title_short | Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (<it>Macaca nigra</it>) |
| title_sort | immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque it macaca nigra it |
| topic | Neoplasm Small bowel <it>Macaca</it> Monkey Leiomyoma Intestine |
| url | http://www.biomedcentral.com/1746-6148/8/97 |
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