Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects
Analysis of heart rate variability (HRV) can be applied to assess the autonomic nervous system (ANS) sympathetic and parasympathetic activity. Since living systems are non-linear, evaluation of ANS activity is difficult by means of linear methods. We propose to apply the Higuchi fractal dimension (H...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01162/full |
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| author | Ryszard S. Gomolka Stefan Kampusch Eugenijus Kaniusas Florian Thürk Jozsef C. Széles Wlodzimierz Klonowski |
| author_facet | Ryszard S. Gomolka Stefan Kampusch Eugenijus Kaniusas Florian Thürk Jozsef C. Széles Wlodzimierz Klonowski |
| author_sort | Ryszard S. Gomolka |
| collection | DOAJ |
| description | Analysis of heart rate variability (HRV) can be applied to assess the autonomic nervous system (ANS) sympathetic and parasympathetic activity. Since living systems are non-linear, evaluation of ANS activity is difficult by means of linear methods. We propose to apply the Higuchi fractal dimension (HFD) method for assessment of ANS activity. HFD measures complexity of the HRV signal. We analyzed 45 RR time series of 84 min duration each from nine healthy and five diabetic subjects with clinically confirmed long-term diabetes mellitus type II and with diabetic foot ulcer lasting more than 6 weeks. Based on HRV time series complexity analysis we have shown that HFD: (1) discriminates healthy subjects from patients with diabetes mellitus type II; (2) assesses the impact of percutaneous auricular vagus nerve stimulation (pVNS) on ANS activity in normal and diabetic conditions. Thus, HFD may be used during pVNS treatment, to provide stimulation feedback for on-line regulation of therapy in a fast and robust way. |
| first_indexed | 2024-12-22T12:37:50Z |
| format | Article |
| id | doaj.art-d8c8bc5c28d848698b7b1a087bf0017f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T12:37:50Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-d8c8bc5c28d848698b7b1a087bf0017f2022-12-21T18:25:32ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-08-01910.3389/fphys.2018.01162 350936Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic SubjectsRyszard S. Gomolka0Stefan Kampusch1Eugenijus Kaniusas2Florian Thürk3Jozsef C. Széles4Wlodzimierz Klonowski5Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, PolandInstitute of Electrodynamics, Microwave and Circuit Engineering, TU Wien, Vienna, AustriaInstitute of Electrodynamics, Microwave and Circuit Engineering, TU Wien, Vienna, AustriaInstitute of Electrodynamics, Microwave and Circuit Engineering, TU Wien, Vienna, AustriaDivision of Vascular Surgery, University Clinic for Surgery, Medical University of Vienna, Vienna, AustriaNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, PolandAnalysis of heart rate variability (HRV) can be applied to assess the autonomic nervous system (ANS) sympathetic and parasympathetic activity. Since living systems are non-linear, evaluation of ANS activity is difficult by means of linear methods. We propose to apply the Higuchi fractal dimension (HFD) method for assessment of ANS activity. HFD measures complexity of the HRV signal. We analyzed 45 RR time series of 84 min duration each from nine healthy and five diabetic subjects with clinically confirmed long-term diabetes mellitus type II and with diabetic foot ulcer lasting more than 6 weeks. Based on HRV time series complexity analysis we have shown that HFD: (1) discriminates healthy subjects from patients with diabetes mellitus type II; (2) assesses the impact of percutaneous auricular vagus nerve stimulation (pVNS) on ANS activity in normal and diabetic conditions. Thus, HFD may be used during pVNS treatment, to provide stimulation feedback for on-line regulation of therapy in a fast and robust way.https://www.frontiersin.org/article/10.3389/fphys.2018.01162/fullHiguchi fractal dimensionheart rate variabilityautonomic nervous systemvagus nerve stimulationdiabetes |
| spellingShingle | Ryszard S. Gomolka Stefan Kampusch Eugenijus Kaniusas Florian Thürk Jozsef C. Széles Wlodzimierz Klonowski Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects Frontiers in Physiology Higuchi fractal dimension heart rate variability autonomic nervous system vagus nerve stimulation diabetes |
| title | Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects |
| title_full | Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects |
| title_fullStr | Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects |
| title_full_unstemmed | Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects |
| title_short | Higuchi Fractal Dimension of Heart Rate Variability During Percutaneous Auricular Vagus Nerve Stimulation in Healthy and Diabetic Subjects |
| title_sort | higuchi fractal dimension of heart rate variability during percutaneous auricular vagus nerve stimulation in healthy and diabetic subjects |
| topic | Higuchi fractal dimension heart rate variability autonomic nervous system vagus nerve stimulation diabetes |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01162/full |
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