Analysis of risk factors for infection after transrectal ultrasound-guided prostate biopsy and analysis of the value of preoperative prophylactic antimicrobial use
This study aimed to identify risk factors associated with infections after Transrectal ultrasound-guided prostate biopsy (TRUSPB) and to analyze the efficacy of preoperative prophylactic antimicrobial administration. A retrospective analysis was conducted on 766 patients who underwent TRUSPB at o...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2023-12-01
|
| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20231229-164/pdf/JOMH2023070701.pdf |
| _version_ | 1797359860281507840 |
|---|---|
| author | Jing Li Linjie Wang |
| author_facet | Jing Li Linjie Wang |
| author_sort | Jing Li |
| collection | DOAJ |
| description | This study aimed to identify risk factors associated with infections after
Transrectal ultrasound-guided prostate biopsy (TRUSPB) and to analyze the
efficacy of preoperative prophylactic antimicrobial administration. A
retrospective analysis was conducted on 766 patients who underwent TRUSPB at our
hospital from January 2020 to January 2023. Among them, 450 patients were given a
three-day prophylactic course of antimicrobial fluoroquinolones before TRUSPB
(Group A), while the remaining 316 patients were administered a single dose of
750 mg oral ciprofloxacin 1 h before TRUSPB (Group B). We calculated the
incidence of post-TRUSPB infections in both groups and employed a binary logistic
regression model to analyze factors influencing post-TRUSPB infections and
evaluate the effectiveness of prophylactic antimicrobial use. Among the 766
patients who underwent prostate biopsy, 62 cases (8.1%) developed post-TRUSPB
infections, and there was no statistically significant difference in the rate of
post-TRUSPB infections and types of infections between Group A and Group B. Blood
and urine cultures from all the 62 infected patients were positive, with
Escherichia coli being the most commonly detected pathogen, demonstrating a
positive detection rate of 100.0% and accounting for 76% of all infections.
Logistic regression analysis identified age (Odds ratio (OR) = 1.15, 95%
Confidence Interval (CI) 1.05–1.25), a history of diabetes mellitus (OR = 1.31,
95% CI 1.12–1.52), and history of indwelling urinary catheter within 7 days
before biopsy (OR = 1.43, 95% CI 1.15–1.77) as risk factors for post-TRUSPB
infections. In summary, a single application of ciprofloxacin demonstrated
similar efficacy in reducing the risk of post-TRUSPB infection compared to a
three-day course of oral fluoroquinolones before biopsy while also reducing the
risk of quinolone resistance. Conversely, advanced age, comorbid diabetes
mellitus, and a 7-day history of indwelling urinary catheter before TRUSPB
increased the risk of post-TRUSPB infection. |
| first_indexed | 2024-03-08T15:29:54Z |
| format | Article |
| id | doaj.art-d8ca6993ab5944deb880cb5c2f85b625 |
| institution | Directory Open Access Journal |
| issn | 1875-6867 1875-6859 |
| language | English |
| last_indexed | 2024-03-08T15:29:54Z |
| publishDate | 2023-12-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj.art-d8ca6993ab5944deb880cb5c2f85b6252024-01-10T06:39:50ZengMRE PressJournal of Men's Health1875-68671875-68592023-12-011912606510.22514/jomh.2023.130S1875-6867(23)00099-4Analysis of risk factors for infection after transrectal ultrasound-guided prostate biopsy and analysis of the value of preoperative prophylactic antimicrobial useJing Li0Linjie Wang1Hospital infection management office, the First Affiliated Hospital of Shihezi University, 832008 Shihezi, Xinjiang Uygur Autonomous Region, ChinaFirst Clinical College, Changsha Medical University, 410219 Changsha, Hunan, ChinaThis study aimed to identify risk factors associated with infections after Transrectal ultrasound-guided prostate biopsy (TRUSPB) and to analyze the efficacy of preoperative prophylactic antimicrobial administration. A retrospective analysis was conducted on 766 patients who underwent TRUSPB at our hospital from January 2020 to January 2023. Among them, 450 patients were given a three-day prophylactic course of antimicrobial fluoroquinolones before TRUSPB (Group A), while the remaining 316 patients were administered a single dose of 750 mg oral ciprofloxacin 1 h before TRUSPB (Group B). We calculated the incidence of post-TRUSPB infections in both groups and employed a binary logistic regression model to analyze factors influencing post-TRUSPB infections and evaluate the effectiveness of prophylactic antimicrobial use. Among the 766 patients who underwent prostate biopsy, 62 cases (8.1%) developed post-TRUSPB infections, and there was no statistically significant difference in the rate of post-TRUSPB infections and types of infections between Group A and Group B. Blood and urine cultures from all the 62 infected patients were positive, with Escherichia coli being the most commonly detected pathogen, demonstrating a positive detection rate of 100.0% and accounting for 76% of all infections. Logistic regression analysis identified age (Odds ratio (OR) = 1.15, 95% Confidence Interval (CI) 1.05–1.25), a history of diabetes mellitus (OR = 1.31, 95% CI 1.12–1.52), and history of indwelling urinary catheter within 7 days before biopsy (OR = 1.43, 95% CI 1.15–1.77) as risk factors for post-TRUSPB infections. In summary, a single application of ciprofloxacin demonstrated similar efficacy in reducing the risk of post-TRUSPB infection compared to a three-day course of oral fluoroquinolones before biopsy while also reducing the risk of quinolone resistance. Conversely, advanced age, comorbid diabetes mellitus, and a 7-day history of indwelling urinary catheter before TRUSPB increased the risk of post-TRUSPB infection.https://oss.jomh.org/files/article/20231229-164/pdf/JOMH2023070701.pdfantibiotic prophylaxisparacentesiswound infection |
| spellingShingle | Jing Li Linjie Wang Analysis of risk factors for infection after transrectal ultrasound-guided prostate biopsy and analysis of the value of preoperative prophylactic antimicrobial use Journal of Men's Health antibiotic prophylaxis paracentesis wound infection |
| title | Analysis of risk factors for infection after transrectal
ultrasound-guided prostate biopsy and analysis of the value of preoperative
prophylactic antimicrobial use |
| title_full | Analysis of risk factors for infection after transrectal
ultrasound-guided prostate biopsy and analysis of the value of preoperative
prophylactic antimicrobial use |
| title_fullStr | Analysis of risk factors for infection after transrectal
ultrasound-guided prostate biopsy and analysis of the value of preoperative
prophylactic antimicrobial use |
| title_full_unstemmed | Analysis of risk factors for infection after transrectal
ultrasound-guided prostate biopsy and analysis of the value of preoperative
prophylactic antimicrobial use |
| title_short | Analysis of risk factors for infection after transrectal
ultrasound-guided prostate biopsy and analysis of the value of preoperative
prophylactic antimicrobial use |
| title_sort | analysis of risk factors for infection after transrectal ultrasound guided prostate biopsy and analysis of the value of preoperative prophylactic antimicrobial use |
| topic | antibiotic prophylaxis paracentesis wound infection |
| url | https://oss.jomh.org/files/article/20231229-164/pdf/JOMH2023070701.pdf |
| work_keys_str_mv | AT jingli analysisofriskfactorsforinfectionaftertransrectalultrasoundguidedprostatebiopsyandanalysisofthevalueofpreoperativeprophylacticantimicrobialuse AT linjiewang analysisofriskfactorsforinfectionaftertransrectalultrasoundguidedprostatebiopsyandanalysisofthevalueofpreoperativeprophylacticantimicrobialuse |