Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions
Whole-organ pancreas and islets transplantations are two therapeutic options to treat type 1 diabetic patients resistant to optimised medical treatment in whom severe complications develop. Selection of the best option for β-cell replacement depends on several factors such as kidney function, patien...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/9/3245 |
| _version_ | 1797602332773449728 |
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| author | David Martin Piero Alberti Nicolas Demartines Melanie Phillips John Casey Andrew Sutherland |
| author_facet | David Martin Piero Alberti Nicolas Demartines Melanie Phillips John Casey Andrew Sutherland |
| author_sort | David Martin |
| collection | DOAJ |
| description | Whole-organ pancreas and islets transplantations are two therapeutic options to treat type 1 diabetic patients resistant to optimised medical treatment in whom severe complications develop. Selection of the best option for β-cell replacement depends on several factors such as kidney function, patient comorbidities, and treatment goals. For a patient with end-stage kidney disease, the treatment of choice is often a simultaneous transplant of the pancreas and kidney (SPK). However, it remains a major surgical procedure in patients with multiple comorbidities and therefore it is important to select those who will benefit from it. Additionally, in view of the organ shortage, new strategies to improve outcomes and reduce immune reactions have been developed, including dynamic organ perfusion technologies, pancreas bioengineering, and stem cell therapies. The purpose of this article is to review the indications, surgical techniques, outcomes, and future directions of whole-organ pancreas and islets transplantations. |
| first_indexed | 2024-03-11T04:15:36Z |
| format | Article |
| id | doaj.art-d8cc3a3856344f1eae53f7dc78066cb6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:15:36Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d8cc3a3856344f1eae53f7dc78066cb62023-11-17T23:12:37ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-01129324510.3390/jcm12093245Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future DirectionsDavid Martin0Piero Alberti1Nicolas Demartines2Melanie Phillips3John Casey4Andrew Sutherland5Department of Visceral Surgery and Transplantation, University Hospital CHUV, University of Lausanne (UNIL), 1015 Lausanne, SwitzerlandEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UKDepartment of Visceral Surgery and Transplantation, University Hospital CHUV, University of Lausanne (UNIL), 1015 Lausanne, SwitzerlandEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UKEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UKEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UKWhole-organ pancreas and islets transplantations are two therapeutic options to treat type 1 diabetic patients resistant to optimised medical treatment in whom severe complications develop. Selection of the best option for β-cell replacement depends on several factors such as kidney function, patient comorbidities, and treatment goals. For a patient with end-stage kidney disease, the treatment of choice is often a simultaneous transplant of the pancreas and kidney (SPK). However, it remains a major surgical procedure in patients with multiple comorbidities and therefore it is important to select those who will benefit from it. Additionally, in view of the organ shortage, new strategies to improve outcomes and reduce immune reactions have been developed, including dynamic organ perfusion technologies, pancreas bioengineering, and stem cell therapies. The purpose of this article is to review the indications, surgical techniques, outcomes, and future directions of whole-organ pancreas and islets transplantations.https://www.mdpi.com/2077-0383/12/9/3245pancreas transplantationislets transplantationtype 1 diabetes mellitus |
| spellingShingle | David Martin Piero Alberti Nicolas Demartines Melanie Phillips John Casey Andrew Sutherland Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions Journal of Clinical Medicine pancreas transplantation islets transplantation type 1 diabetes mellitus |
| title | Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions |
| title_full | Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions |
| title_fullStr | Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions |
| title_full_unstemmed | Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions |
| title_short | Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions |
| title_sort | whole organ pancreas and islets transplantations in uk an overview and future directions |
| topic | pancreas transplantation islets transplantation type 1 diabetes mellitus |
| url | https://www.mdpi.com/2077-0383/12/9/3245 |
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