Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model
The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynami...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/2/2052 |
| _version_ | 1818788838353403904 |
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| author | Chi-Chung Wen Zi-Yu Lin Yun-Hsin Wang Wei-Hua Wang Yau-Hung Chen Ching-Yuh Chern |
| author_facet | Chi-Chung Wen Zi-Yu Lin Yun-Hsin Wang Wei-Hua Wang Yau-Hung Chen Ching-Yuh Chern |
| author_sort | Chi-Chung Wen |
| collection | DOAJ |
| description | The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation. |
| first_indexed | 2024-12-18T14:30:02Z |
| format | Article |
| id | doaj.art-d8ccd7a362794b5d938729afaf5fd033 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T14:30:02Z |
| publishDate | 2013-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d8ccd7a362794b5d938729afaf5fd0332022-12-21T21:04:37ZengMDPI AGMolecules1420-30492013-02-011822052206010.3390/molecules18022052Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish ModelChi-Chung WenZi-Yu LinYun-Hsin WangWei-Hua WangYau-Hung ChenChing-Yuh ChernThe aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.http://www.mdpi.com/1420-3049/18/2/2052anti-inflammationchalconefinzebrafish |
| spellingShingle | Chi-Chung Wen Zi-Yu Lin Yun-Hsin Wang Wei-Hua Wang Yau-Hung Chen Ching-Yuh Chern Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model Molecules anti-inflammation chalcone fin zebrafish |
| title | Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model |
| title_full | Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model |
| title_fullStr | Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model |
| title_full_unstemmed | Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model |
| title_short | Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model |
| title_sort | evaluation of the anti inflammatory effect of chalcone and chalcone analogues in a zebrafish model |
| topic | anti-inflammation chalcone fin zebrafish |
| url | http://www.mdpi.com/1420-3049/18/2/2052 |
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