Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients
ObjectiveTo characterize the PET-MRI co-registration of hypometabolic patterns in focal cortical dysplasia (FCD) types I and II and provide some suggestions in presurgical evaluation of epilepsy surgery.MethodsWe retrospectively analyzed PET-MRI co-registration imaging data from a cohort of 83 epile...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1173534/full |
| _version_ | 1797674019501113344 |
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| author | Xiu Wang Wenhan Hu Wenhan Hu Xiaoqiu Shao Zhong Zheng Lin Ai Lin Sang Chao Zhang Chao Zhang Jian-guo Zhang Jian-guo Zhang Jian-guo Zhang Kai Zhang Kai Zhang |
| author_facet | Xiu Wang Wenhan Hu Wenhan Hu Xiaoqiu Shao Zhong Zheng Lin Ai Lin Sang Chao Zhang Chao Zhang Jian-guo Zhang Jian-guo Zhang Jian-guo Zhang Kai Zhang Kai Zhang |
| author_sort | Xiu Wang |
| collection | DOAJ |
| description | ObjectiveTo characterize the PET-MRI co-registration of hypometabolic patterns in focal cortical dysplasia (FCD) types I and II and provide some suggestions in presurgical evaluation of epilepsy surgery.MethodsWe retrospectively analyzed PET-MRI co-registration imaging data from a cohort of 83 epilepsy patients with histologically confirmed FCD types I and II. Hypometabolic patterns were classified into 4 types: bottom of sulcus hypometabolism (BOSH), single island of sulcus hypometabolism (SIOS), single gyrus or sulcus hypometabolism (SGOS), and multiple gyri and sulci hypometabolism (MGOS).ResultsMost of cases that were overlooked by conventional MRI and PET evaluation but positive in PET-MRI co-registration were focalized lesions in dorsolateral frontal lobe (9/15) and FCD type IIa was the most prevalent pathological type (11/15). The FCD histological types (p = 0.027) and locations (p < 0.001) were independent predictors of PET-MRI co-registration hypometabolic patterns. Focalized hypometabolic patterns (BOSH, SIOS, SGOS) were primarily observed in the frontal lobe (33/39) and FCD type II (43/62) and extensive pattern (MGOS) in temporal lobe (18/20) and FCD type I (16/21; p < 0.005).ConclusionPET-MRI co-registration enhanced the detection of FCD type IIa compared with conventional MRI and PET reading. The hypometabolic patterns of FCD type I and temporal lobe FCD were more extensive than those of FCD type II and frontal lobe FCD, respectively. The predilection of focalized hypometabolic patterns in frontal lobe FCD suggested that subtle lesions should be checked carefully in patients with suspected frontal lobe epilepsy. |
| first_indexed | 2024-03-11T21:53:05Z |
| format | Article |
| id | doaj.art-d8ce122720e042c69460e47243fd01a6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-11T21:53:05Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d8ce122720e042c69460e47243fd01a62023-09-26T06:52:07ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.11735341173534Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patientsXiu Wang0Wenhan Hu1Wenhan Hu2Xiaoqiu Shao3Zhong Zheng4Lin Ai5Lin Sang6Chao Zhang7Chao Zhang8Jian-guo Zhang9Jian-guo Zhang10Jian-guo Zhang11Kai Zhang12Kai Zhang13Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaStereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaEpilepsy Center, Medical Alliance of Beijing Tian Tan Hospital, Peking University First Hospital Fengtai Hospital, Beijing, ChinaDepartment of Nuclear Medicine, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaEpilepsy Center, Medical Alliance of Beijing Tian Tan Hospital, Peking University First Hospital Fengtai Hospital, Beijing, ChinaDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaStereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaObjectiveTo characterize the PET-MRI co-registration of hypometabolic patterns in focal cortical dysplasia (FCD) types I and II and provide some suggestions in presurgical evaluation of epilepsy surgery.MethodsWe retrospectively analyzed PET-MRI co-registration imaging data from a cohort of 83 epilepsy patients with histologically confirmed FCD types I and II. Hypometabolic patterns were classified into 4 types: bottom of sulcus hypometabolism (BOSH), single island of sulcus hypometabolism (SIOS), single gyrus or sulcus hypometabolism (SGOS), and multiple gyri and sulci hypometabolism (MGOS).ResultsMost of cases that were overlooked by conventional MRI and PET evaluation but positive in PET-MRI co-registration were focalized lesions in dorsolateral frontal lobe (9/15) and FCD type IIa was the most prevalent pathological type (11/15). The FCD histological types (p = 0.027) and locations (p < 0.001) were independent predictors of PET-MRI co-registration hypometabolic patterns. Focalized hypometabolic patterns (BOSH, SIOS, SGOS) were primarily observed in the frontal lobe (33/39) and FCD type II (43/62) and extensive pattern (MGOS) in temporal lobe (18/20) and FCD type I (16/21; p < 0.005).ConclusionPET-MRI co-registration enhanced the detection of FCD type IIa compared with conventional MRI and PET reading. The hypometabolic patterns of FCD type I and temporal lobe FCD were more extensive than those of FCD type II and frontal lobe FCD, respectively. The predilection of focalized hypometabolic patterns in frontal lobe FCD suggested that subtle lesions should be checked carefully in patients with suspected frontal lobe epilepsy.https://www.frontiersin.org/articles/10.3389/fnins.2023.1173534/fullPET-MRI co-registrationfocal cortical dysplasiaepilepsyhypometabolic patternPET |
| spellingShingle | Xiu Wang Wenhan Hu Wenhan Hu Xiaoqiu Shao Zhong Zheng Lin Ai Lin Sang Chao Zhang Chao Zhang Jian-guo Zhang Jian-guo Zhang Jian-guo Zhang Kai Zhang Kai Zhang Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients Frontiers in Neuroscience PET-MRI co-registration focal cortical dysplasia epilepsy hypometabolic pattern PET |
| title | Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients |
| title_full | Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients |
| title_fullStr | Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients |
| title_full_unstemmed | Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients |
| title_short | Hypometabolic patterns of focal cortical dysplasia in PET-MRI co-registration imaging: a retrospective evaluation in a series of 83 patients |
| title_sort | hypometabolic patterns of focal cortical dysplasia in pet mri co registration imaging a retrospective evaluation in a series of 83 patients |
| topic | PET-MRI co-registration focal cortical dysplasia epilepsy hypometabolic pattern PET |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1173534/full |
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