Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase

Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase

ABSTRACTMultidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public health. In the search for new treatment options, P. a...

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Bibliographic Details
Main Authors: Larissa Dirr, Sven Cleeves, Isabel Ramón Roth, Linghui Li, Timm Fiebig, Thomas Ve, Susanne Häussler, Armin Braun, Mark von Itzstein, Jana I. Führing
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
drug targets
Pseudomonas aeruginosa
protein structure-function
virulence factors
lipopolysaccharide
virulence
Online Access:https://journals.asm.org/doi/10.1128/mbio.02114-23

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