Loss of Asxl2 leads to myeloid malignancies in mice

Loss of Asxl2 leads to myeloid malignancies in mice

ASXL2 mutations are mostly found in a subset of leukemia patients with certain genetic aberrations; however the role of this protein in normal hematopoiesis and related malignancies is still unclear. Here the authors use a knock-out mouse model to uncover the role of Asxl2in hematopoiesis and leukem...

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Podrobná bibliografie
Hlavní autoři: Jianping Li, Fuhong He, Peng Zhang, Shi Chen, Hui Shi, Yanling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen D. Nimer, Peng Yu, Qian-Fei Wang, Mingjiang Xu, Feng-Chun Yang
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2017-06-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/ncomms15456

Internet

https://doi.org/10.1038/ncomms15456

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