Role of Transient Receptor Potential Vanilloid 4 in Vascular Function
Transient receptor potential vanilloid 4 (TRPV4) channels are widely expressed in systemic tissues and can be activated by many stimuli. TRPV4, a Ca2+-permeable cation channel, plays an important role in the vasculature and is implicated in the regulation of cardiovascular homeostasis processes such...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.677661/full |
| _version_ | 1818596093115498496 |
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| author | Liangliang Liu Mengting Guo Xiaowang Lv Zhiwei Wang Jigang Yang Yanting Li Fan Yu Xin Wen Lei Feng Tingting Zhou |
| author_facet | Liangliang Liu Mengting Guo Xiaowang Lv Zhiwei Wang Jigang Yang Yanting Li Fan Yu Xin Wen Lei Feng Tingting Zhou |
| author_sort | Liangliang Liu |
| collection | DOAJ |
| description | Transient receptor potential vanilloid 4 (TRPV4) channels are widely expressed in systemic tissues and can be activated by many stimuli. TRPV4, a Ca2+-permeable cation channel, plays an important role in the vasculature and is implicated in the regulation of cardiovascular homeostasis processes such as blood pressure, vascular remodeling, and pulmonary hypertension and edema. Within the vasculature, TRPV4 channels are expressed in smooth muscle cells, endothelial cells, and perivascular nerves. The activation of endothelial TRPV4 contributes to vasodilation involving nitric oxide, prostacyclin, and endothelial-derived hyperpolarizing factor pathways. TRPV4 activation also can directly cause vascular smooth muscle cell hyperpolarization and vasodilation. In addition, TRPV4 activation can evoke constriction in some specific vascular beds or under some pathological conditions. TRPV4 participates in the control of vascular permeability and vascular damage, particularly in the lung capillary endothelial barrier and lung injury. It also participates in vascular remodeling regulation mainly by controlling vasculogenesis and arteriogenesis. This review examines the role of TRPV4 in vascular function, particularly in vascular dilation and constriction, vascular permeability, vascular remodeling, and vascular damage, along with possible mechanisms, and discusses the possibility of targeting TRPV4 for therapy. |
| first_indexed | 2024-12-16T11:26:25Z |
| format | Article |
| id | doaj.art-d8d0c92aea434eb3a1a30fb55f1bee30 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-16T11:26:25Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-d8d0c92aea434eb3a1a30fb55f1bee302022-12-21T22:33:21ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-04-01810.3389/fmolb.2021.677661677661Role of Transient Receptor Potential Vanilloid 4 in Vascular FunctionLiangliang LiuMengting GuoXiaowang LvZhiwei WangJigang YangYanting LiFan YuXin WenLei FengTingting ZhouTransient receptor potential vanilloid 4 (TRPV4) channels are widely expressed in systemic tissues and can be activated by many stimuli. TRPV4, a Ca2+-permeable cation channel, plays an important role in the vasculature and is implicated in the regulation of cardiovascular homeostasis processes such as blood pressure, vascular remodeling, and pulmonary hypertension and edema. Within the vasculature, TRPV4 channels are expressed in smooth muscle cells, endothelial cells, and perivascular nerves. The activation of endothelial TRPV4 contributes to vasodilation involving nitric oxide, prostacyclin, and endothelial-derived hyperpolarizing factor pathways. TRPV4 activation also can directly cause vascular smooth muscle cell hyperpolarization and vasodilation. In addition, TRPV4 activation can evoke constriction in some specific vascular beds or under some pathological conditions. TRPV4 participates in the control of vascular permeability and vascular damage, particularly in the lung capillary endothelial barrier and lung injury. It also participates in vascular remodeling regulation mainly by controlling vasculogenesis and arteriogenesis. This review examines the role of TRPV4 in vascular function, particularly in vascular dilation and constriction, vascular permeability, vascular remodeling, and vascular damage, along with possible mechanisms, and discusses the possibility of targeting TRPV4 for therapy.https://www.frontiersin.org/articles/10.3389/fmolb.2021.677661/fullTRPV4vasodilationvasoconstrictionvascular permeabilityvascular remodelingvascular damage |
| spellingShingle | Liangliang Liu Mengting Guo Xiaowang Lv Zhiwei Wang Jigang Yang Yanting Li Fan Yu Xin Wen Lei Feng Tingting Zhou Role of Transient Receptor Potential Vanilloid 4 in Vascular Function Frontiers in Molecular Biosciences TRPV4 vasodilation vasoconstriction vascular permeability vascular remodeling vascular damage |
| title | Role of Transient Receptor Potential Vanilloid 4 in Vascular Function |
| title_full | Role of Transient Receptor Potential Vanilloid 4 in Vascular Function |
| title_fullStr | Role of Transient Receptor Potential Vanilloid 4 in Vascular Function |
| title_full_unstemmed | Role of Transient Receptor Potential Vanilloid 4 in Vascular Function |
| title_short | Role of Transient Receptor Potential Vanilloid 4 in Vascular Function |
| title_sort | role of transient receptor potential vanilloid 4 in vascular function |
| topic | TRPV4 vasodilation vasoconstriction vascular permeability vascular remodeling vascular damage |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.677661/full |
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