GPR35 antagonist CID-2745687 attenuates anchorage-independent cell growth by inhibiting YAP/TAZ activity in colorectal cancer cells

GPR35 antagonist CID-2745687 attenuates anchorage-independent cell growth by inhibiting YAP/TAZ activity in colorectal cancer cells

Background and purpose: GPR35, a member of the orphan G-protein-coupled receptor, was recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by antagonists can inhibit its pro-cancer role has yet to be answered.Experimental approach: We applied antagonist CID-2745687 (CID)...

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Bibliographic Details
Main Authors: Wuxiyar Otkur, Xiaolong Liu, Huan Chen, Siyi Li, Ting Ling, Hanchen Lin, Renyu Yang, Tian Xia, Huan Qi, Hai-Long Piao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
GPR35
colorectal cancer
YAP/TAZ
anchorage-independent growth
antagonist
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1126119/full

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