The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function

The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function

The NLRP3 inflammasome is a supramolecular complex that is linked to sterile and pathogen-dependent inflammation, and its excessive activation underlies many diseases. Ion flux disturbance and cell volume regulation are both reported to mediate NLRP3 inflammasome activation, but the underlying orche...

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Bibliographic Details
Main Authors: Xiaoyan Wu, Xin Yi, Boxin Zhao, Yuanxing Zhi, Ziwei Xu, Ying Cao, Xiong Cao, Jianxin Pang, Ken Kin Lam Yung, Shiqing Zhang, Shuwen Liu, Pingzheng Zhou
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Pharmacological Research
Subjects:
LRRC8
Cell volume regulation
Innate immunity
Sepsis
Macrophage activation
Immunometabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003729

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