How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials
<p>Abstract</p> <p>Background</p> <p>To speed up the evaluation of new therapies, the multi-arm, multi-stage trial design was suggested previously by the authors.</p> <p>Methods</p> <p>In this paper, we evaluate the performance of the two-stage,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-04-01
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| Series: | Trials |
| Online Access: | http://www.trialsjournal.com/content/10/1/21 |
| _version_ | 1811265464459853824 |
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| author | Barthel FM-S Parmar MKB Royston P |
| author_facet | Barthel FM-S Parmar MKB Royston P |
| author_sort | Barthel FM-S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To speed up the evaluation of new therapies, the multi-arm, multi-stage trial design was suggested previously by the authors.</p> <p>Methods</p> <p>In this paper, we evaluate the performance of the two-stage, multi-arm design using four cancer trials conducted at the MRC CTU. The performance of the design at fictitious interim analyses is assessed using a conditional bootstrap approach.</p> <p>Results</p> <p>Two main aims are addressed: the error rate of correctly carrying on/stopping the trial at an interim analysis as well as quantifying the gains in terms of resources by employing this design. Furthermore, we make suggestions for the best timing of this interim analysis.</p> <p>Conclusion</p> <p>Multi-arm, multi-stage trials are an effective way of speeding up the therapy evaluation process. The design performs well in terms of the type I and II error rates.</p> |
| first_indexed | 2024-04-12T20:24:20Z |
| format | Article |
| id | doaj.art-d8d50d75f1564486a1c745091df30c20 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-12T20:24:20Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-d8d50d75f1564486a1c745091df30c202022-12-22T03:17:55ZengBMCTrials1745-62152009-04-011012110.1186/1745-6215-10-21How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trialsBarthel FM-SParmar MKBRoyston P<p>Abstract</p> <p>Background</p> <p>To speed up the evaluation of new therapies, the multi-arm, multi-stage trial design was suggested previously by the authors.</p> <p>Methods</p> <p>In this paper, we evaluate the performance of the two-stage, multi-arm design using four cancer trials conducted at the MRC CTU. The performance of the design at fictitious interim analyses is assessed using a conditional bootstrap approach.</p> <p>Results</p> <p>Two main aims are addressed: the error rate of correctly carrying on/stopping the trial at an interim analysis as well as quantifying the gains in terms of resources by employing this design. Furthermore, we make suggestions for the best timing of this interim analysis.</p> <p>Conclusion</p> <p>Multi-arm, multi-stage trials are an effective way of speeding up the therapy evaluation process. The design performs well in terms of the type I and II error rates.</p>http://www.trialsjournal.com/content/10/1/21 |
| spellingShingle | Barthel FM-S Parmar MKB Royston P How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials Trials |
| title | How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials |
| title_full | How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials |
| title_fullStr | How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials |
| title_full_unstemmed | How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials |
| title_short | How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials |
| title_sort | how do multi stage multi arm trials compare to the traditional two arm parallel group design a reanalysis of 4 trials |
| url | http://www.trialsjournal.com/content/10/1/21 |
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