Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-κB/slug/E-cadherin pathway

Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-κB/slug/E-cadherin pathway

Abstract Background Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. Methods To investigate the effects and mechanisms of genis...

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Bibliographic Details
Main Authors: Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi, Aike Li
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Cancer
Subjects:
Genistein
Colon cancer cell
Apoptosis
Epithelial mesenchymal transition
Online Access:http://link.springer.com/article/10.1186/s12885-017-3829-9

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