HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program

Abstract Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and serves as a promising therapeutic target....

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Bibliographic Details
Main Authors: Ming Huang, Wen Dong, Ruihui Xie, Jilin Wu, Qiao Su, Wuguo Li, Kai Yao, Yuelong Chen, Qianghua Zhou, Qiang Zhang, Wenwen Li, Liang Cheng, Shengmeng Peng, Siting Chen, Jian Huang, Xu Chen, Tianxin Lin
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Cancer Communications
Subjects:
HSF1
PRMT5
KRIBB11
transcriptional program
bladder cancer
lymphatic metastasis
Online Access:https://doi.org/10.1002/cac2.12284

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