STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE
Aim of the study was to investigate the possible mutagenic properties of a new drug based on a lithium-containing substance – a complex of lithium citrate, polymethylsiloxane and aluminum oxide. Material and methods. Methods for testing mutagenicity using chromosomal aberrations in the bone marrow c...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-11-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/276 |
| _version_ | 1797269561013174272 |
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| author | V. I. Konenkov M. A. Korolev A. A. Churin O. L. Voronova O. V. Neupokoeva L. N. Rachkovskaya A. V. Shurlygina M. V. Robinson A. A. Kotlyarova T. V. Popova E. E. Rachkovskiy P. G. Madonov A. Yu. Letyagin |
| author_facet | V. I. Konenkov M. A. Korolev A. A. Churin O. L. Voronova O. V. Neupokoeva L. N. Rachkovskaya A. V. Shurlygina M. V. Robinson A. A. Kotlyarova T. V. Popova E. E. Rachkovskiy P. G. Madonov A. Yu. Letyagin |
| author_sort | V. I. Konenkov |
| collection | DOAJ |
| description | Aim of the study was to investigate the possible mutagenic properties of a new drug based on a lithium-containing substance – a complex of lithium citrate, polymethylsiloxane and aluminum oxide. Material and methods. Methods for testing mutagenicity using chromosomal aberrations in the bone marrow cells of CBA mice and somatic recombination in Drosophila melanogaster were used. Results. It was shown that a single intragastric administration of drug at a dose of 5000 mg/kg and a fivefold course of administration at a dose of 400 mg/kg to CBA mice did not increase the level of cytogenetic disorders in bone marrow cells. The study of the lithium complex drug in a somatic mosaicism test revealed that the preparation at a dose of 2000 mg/kg does not increase the frequency of mutations in Drosophila melanogaster. Conclusion. A single intragastric administration of the studied drug at a dose of 5000 mg/kg and its course administration (400 mg/kg × 5) do not increase the level of cytogenetic disorders in the bone marrow cells of CBA mice. In the somatic recombination (mosaicism) test system on D. melanogaster, no increase in the appearance of mutant setae and spots on the body and head was observed when using yellow and singed markers. The results of the study indicate that the studied drug does not have mutagenic properties. |
| first_indexed | 2024-03-08T14:34:34Z |
| format | Article |
| id | doaj.art-d8d9d8b90c8a411881ce0d282633270b |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2024-04-25T01:50:19Z |
| publishDate | 2019-11-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-d8d9d8b90c8a411881ce0d282633270b2024-03-07T18:49:58ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-11-01395626710.15372/SSMJ20190507188STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANEV. I. Konenkov0M. A. Korolev1A. A. Churin2O. L. Voronova3O. V. Neupokoeva4L. N. Rachkovskaya5A. V. Shurlygina6M. V. Robinson7A. A. Kotlyarova8T. V. Popova9E. E. Rachkovskiy10P. G. Madonov11A. Yu. Letyagin12Research Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Scientific Research CenterGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Scientific Research CenterGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Scientific Research CenterResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASAim of the study was to investigate the possible mutagenic properties of a new drug based on a lithium-containing substance – a complex of lithium citrate, polymethylsiloxane and aluminum oxide. Material and methods. Methods for testing mutagenicity using chromosomal aberrations in the bone marrow cells of CBA mice and somatic recombination in Drosophila melanogaster were used. Results. It was shown that a single intragastric administration of drug at a dose of 5000 mg/kg and a fivefold course of administration at a dose of 400 mg/kg to CBA mice did not increase the level of cytogenetic disorders in bone marrow cells. The study of the lithium complex drug in a somatic mosaicism test revealed that the preparation at a dose of 2000 mg/kg does not increase the frequency of mutations in Drosophila melanogaster. Conclusion. A single intragastric administration of the studied drug at a dose of 5000 mg/kg and its course administration (400 mg/kg × 5) do not increase the level of cytogenetic disorders in the bone marrow cells of CBA mice. In the somatic recombination (mosaicism) test system on D. melanogaster, no increase in the appearance of mutant setae and spots on the body and head was observed when using yellow and singed markers. The results of the study indicate that the studied drug does not have mutagenic properties.https://sibmed.elpub.ru/jour/article/view/276mutagenicitydrug based on complex lithium citratepolymethylsiloxane and alumina oxidedrosophila melanogastersomatic recombinationcba micepreclinical research |
| spellingShingle | V. I. Konenkov M. A. Korolev A. A. Churin O. L. Voronova O. V. Neupokoeva L. N. Rachkovskaya A. V. Shurlygina M. V. Robinson A. A. Kotlyarova T. V. Popova E. E. Rachkovskiy P. G. Madonov A. Yu. Letyagin STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE Сибирский научный медицинский журнал mutagenicity drug based on complex lithium citrate polymethylsiloxane and alumina oxide drosophila melanogaster somatic recombination cba mice preclinical research |
| title | STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE |
| title_full | STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE |
| title_fullStr | STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE |
| title_full_unstemmed | STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE |
| title_short | STUDYING THE POSSIBLE MUTAGENIC PROPERTIES OF NEW MEDICINE ON THE BASIS OF COMPLEX LITHIUM CITRATE, ALUMINUM OXIDE AND POLYMETHILSILOXANE |
| title_sort | studying the possible mutagenic properties of new medicine on the basis of complex lithium citrate aluminum oxide and polymethilsiloxane |
| topic | mutagenicity drug based on complex lithium citrate polymethylsiloxane and alumina oxide drosophila melanogaster somatic recombination cba mice preclinical research |
| url | https://sibmed.elpub.ru/jour/article/view/276 |
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