Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice

Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice

This study aimed to investigate the relationship between interleukin (IL)-35 level and IL-35-producing regulatory T cells (iTr35 subset) in Mycobacterium tuberculosis (Mtb)-infected mice. After the mice were injected with Mtb strain H37R via tail vein, the bacterial burden, lung lesions, and the imp...

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Bibliographic Details
Main Authors: Yu Fangliu, Zhu Xinying, Li Qingdeng, Xu Wenqin, Gao Yunxing, Wen Yufeng, Zhang Qiong, Dou Jun
Format: Article
Language:English
Published: De Gruyter 2022-03-01
Series:Open Life Sciences
Subjects:
mycobacterium tuberculosis
h37ra
il-35
il-35-secreting regulatory t cells
immune suppression
Online Access:https://doi.org/10.1515/biol-2022-0025

Internet

https://doi.org/10.1515/biol-2022-0025

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