HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population
Introduction: In Colombia, despite the fact that kidney transplants are the most common type of transplant surgery, a great number of transplanted patients do not achieve the desired Human Leucocyte Antigen (hla) compatibility. hla compatibility plays an important role in graft survival; patients wi...
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| Format: | Article |
| Language: | Spanish |
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Universidad Colegio Mayor Nuestra Señora del Rosario
2016-05-01
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| Series: | Revista Ciencias de la Salud |
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| Online Access: | https://revistas.urosario.edu.co/index.php/revsalud/article/view/4937 |
| _version_ | 1818766218314645504 |
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| author | Oscar Flórez Carmen C. Cabrales Jenny A. Pinto Gerardo Ramírez Julio A. Flórez Adolfo Capella Clara I. González |
| author_facet | Oscar Flórez Carmen C. Cabrales Jenny A. Pinto Gerardo Ramírez Julio A. Flórez Adolfo Capella Clara I. González |
| author_sort | Oscar Flórez |
| collection | DOAJ |
| description | Introduction: In Colombia, despite the fact that kidney transplants are the most common type of transplant surgery, a great number of transplanted patients do not achieve the desired Human Leucocyte Antigen (hla) compatibility. hla compatibility plays an important role in graft survival; patients with matched-hla have a lower chance of graft-versus-host disease and graft ejection. Objective: To determine the probability of finding an hla-matched donor-recipient pairs according to hla−a, −b and −drb1 frequencies in a specific Colombian population. Materials and methods: The study included a total of 484 unrelated individuals (61 donors and 423 recipients) from the hla registry. hla alleles were determined by polymerase chain reaction sequence with specific indicators. Results: hla–A*02, –A*24, –B*35 and –DRB1*04 alleles showed the highest minimum allele frequency (>10%). In addition, hla–A*24–B*35–DRB1*04 was the most frequent extended haplotype in both donors and recipients (7.38 % and 6.76 %, respectively). Our experimental evidence
showed that the maximum chance of finding at least one hla allele-matched kidney is 20.3 % for a patient with the most frequent extended haplotype, whereas for patients with rare or non-common haplotypes this probability is rather unlikely. Discussion: In terms of probability, the chance of finding an hla matched kidney donor/recipients in our region is low. This is due, at least in part, to the higher number of alleles and a the lower donation rate. Therefore, to define the hla profile of a population is important for establishing transplantation programs and alternative strategies in the kidney donation and allocation processes. |
| first_indexed | 2024-12-18T08:30:29Z |
| format | Article |
| id | doaj.art-d8dcc8c0a8a544eea09697592da3132a |
| institution | Directory Open Access Journal |
| issn | 1692-7273 2145-4507 |
| language | Spanish |
| last_indexed | 2024-12-18T08:30:29Z |
| publishDate | 2016-05-01 |
| publisher | Universidad Colegio Mayor Nuestra Señora del Rosario |
| record_format | Article |
| series | Revista Ciencias de la Salud |
| spelling | doaj.art-d8dcc8c0a8a544eea09697592da3132a2022-12-21T21:14:28ZspaUniversidad Colegio Mayor Nuestra Señora del RosarioRevista Ciencias de la Salud1692-72732145-45072016-05-01140210.12804/revsalud14.02.2016.01HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian PopulationOscar Flórez0Carmen C. Cabrales1Jenny A. Pinto2Gerardo RamírezJulio A. Flórez3Adolfo Capella4Clara I. González5Universidad Industrial de SantanderUniversidad Industrial de SantanderUniversidad Industrial de SantanderUniversidad Industrial de SantanderCentro Médico Carlos Ardila LülleUniversidad Industrial de SantanderIntroduction: In Colombia, despite the fact that kidney transplants are the most common type of transplant surgery, a great number of transplanted patients do not achieve the desired Human Leucocyte Antigen (hla) compatibility. hla compatibility plays an important role in graft survival; patients with matched-hla have a lower chance of graft-versus-host disease and graft ejection. Objective: To determine the probability of finding an hla-matched donor-recipient pairs according to hla−a, −b and −drb1 frequencies in a specific Colombian population. Materials and methods: The study included a total of 484 unrelated individuals (61 donors and 423 recipients) from the hla registry. hla alleles were determined by polymerase chain reaction sequence with specific indicators. Results: hla–A*02, –A*24, –B*35 and –DRB1*04 alleles showed the highest minimum allele frequency (>10%). In addition, hla–A*24–B*35–DRB1*04 was the most frequent extended haplotype in both donors and recipients (7.38 % and 6.76 %, respectively). Our experimental evidence showed that the maximum chance of finding at least one hla allele-matched kidney is 20.3 % for a patient with the most frequent extended haplotype, whereas for patients with rare or non-common haplotypes this probability is rather unlikely. Discussion: In terms of probability, the chance of finding an hla matched kidney donor/recipients in our region is low. This is due, at least in part, to the higher number of alleles and a the lower donation rate. Therefore, to define the hla profile of a population is important for establishing transplantation programs and alternative strategies in the kidney donation and allocation processes.https://revistas.urosario.edu.co/index.php/revsalud/article/view/4937Human Leukocyte AntigenKidneyProbabilityMatchingTransplantation |
| spellingShingle | Oscar Flórez Carmen C. Cabrales Jenny A. Pinto Gerardo Ramírez Julio A. Flórez Adolfo Capella Clara I. González HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population Revista Ciencias de la Salud Human Leukocyte Antigen Kidney Probability Matching Transplantation |
| title | HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population |
| title_full | HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population |
| title_fullStr | HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population |
| title_full_unstemmed | HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population |
| title_short | HLA-Matched Donor-Recipient Combinations and Kidney Transplant Probabilities in a Specific Colombian Population |
| title_sort | hla matched donor recipient combinations and kidney transplant probabilities in a specific colombian population |
| topic | Human Leukocyte Antigen Kidney Probability Matching Transplantation |
| url | https://revistas.urosario.edu.co/index.php/revsalud/article/view/4937 |
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