The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
Inflammation is regulated by the host and is a protective response activated by the evolutionarily conserved immune system in response to harmful stimuli, such as dead cells or pathogens. cGAS-STING pathway is a vital natural sensor of host immunity that can defend various tissues and organs against...
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| Format: | Article |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.717610/full |
| _version_ | 1829482698151821312 |
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| author | Zhilei Wang Zhilei Wang Zhilei Wang Nian Chen Zhiyong Li Guang Xu Xiaoyan Zhan Jianyuan Tang Xiaohe Xiao Xiaohe Xiao Xiaohe Xiao Zhaofang Bai Zhaofang Bai |
| author_facet | Zhilei Wang Zhilei Wang Zhilei Wang Nian Chen Zhiyong Li Guang Xu Xiaoyan Zhan Jianyuan Tang Xiaohe Xiao Xiaohe Xiao Xiaohe Xiao Zhaofang Bai Zhaofang Bai |
| author_sort | Zhilei Wang |
| collection | DOAJ |
| description | Inflammation is regulated by the host and is a protective response activated by the evolutionarily conserved immune system in response to harmful stimuli, such as dead cells or pathogens. cGAS-STING pathway is a vital natural sensor of host immunity that can defend various tissues and organs against pathogenic infection, metabolic syndrome, cellular stress and cancer metastasis. The potential impact of cGAS-STING pathway in hepatic ischemia reperfusion (I/R) injury, alcoholic/non-alcoholic steatohepatitis (ASH), hepatic B virus infection, and other liver diseases has recently attracted widespread attention. In this review, the relationship between cGAS-STING pathway and the pathophysiological mechanisms and progression of liver diseases is summarized. Additionally, we discuss various pharmacological agonists and antagonists of cGAS-STING signaling as novel therapeutics for the treatment of liver diseases. A detailed understanding of mechanisms and biology of this pathway will lay a foundation for the development and clinical application of therapies for related liver diseases. |
| first_indexed | 2024-12-14T21:52:53Z |
| format | Article |
| id | doaj.art-d8dd2ac1b2a343f5a1e5b3d7d69f38e6 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T21:52:53Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d8dd2ac1b2a343f5a1e5b3d7d69f38e62022-12-21T22:46:12ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.717610717610The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver DiseasesZhilei Wang0Zhilei Wang1Zhilei Wang2Nian Chen3Zhiyong Li4Guang Xu5Xiaoyan Zhan6Jianyuan Tang7Xiaohe Xiao8Xiaohe Xiao9Xiaohe Xiao10Zhaofang Bai11Zhaofang Bai12TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaDepartment of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChina Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaDepartment of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaChina Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaInflammation is regulated by the host and is a protective response activated by the evolutionarily conserved immune system in response to harmful stimuli, such as dead cells or pathogens. cGAS-STING pathway is a vital natural sensor of host immunity that can defend various tissues and organs against pathogenic infection, metabolic syndrome, cellular stress and cancer metastasis. The potential impact of cGAS-STING pathway in hepatic ischemia reperfusion (I/R) injury, alcoholic/non-alcoholic steatohepatitis (ASH), hepatic B virus infection, and other liver diseases has recently attracted widespread attention. In this review, the relationship between cGAS-STING pathway and the pathophysiological mechanisms and progression of liver diseases is summarized. Additionally, we discuss various pharmacological agonists and antagonists of cGAS-STING signaling as novel therapeutics for the treatment of liver diseases. A detailed understanding of mechanisms and biology of this pathway will lay a foundation for the development and clinical application of therapies for related liver diseases.https://www.frontiersin.org/articles/10.3389/fcell.2021.717610/fullDNA-sensingcyclic GMP-AMP synthasestimulator of interferon genesliver diseasescyclic guanosine monophosphate-adenosine monophosphate |
| spellingShingle | Zhilei Wang Zhilei Wang Zhilei Wang Nian Chen Zhiyong Li Guang Xu Xiaoyan Zhan Jianyuan Tang Xiaohe Xiao Xiaohe Xiao Xiaohe Xiao Zhaofang Bai Zhaofang Bai The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases Frontiers in Cell and Developmental Biology DNA-sensing cyclic GMP-AMP synthase stimulator of interferon genes liver diseases cyclic guanosine monophosphate-adenosine monophosphate |
| title | The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases |
| title_full | The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases |
| title_fullStr | The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases |
| title_full_unstemmed | The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases |
| title_short | The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases |
| title_sort | cytosolic dna sensing cgas sting pathway in liver diseases |
| topic | DNA-sensing cyclic GMP-AMP synthase stimulator of interferon genes liver diseases cyclic guanosine monophosphate-adenosine monophosphate |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.717610/full |
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