Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis
<i>Background and Objectives</i>: Korean and traditional Chinese medicine state that pyrite is effective for fracture treatment, but supporting clinical data are limited. This systematic review aimed to investigate the therapeutic role of Chinese patent medicine containing pyrite (CPMP)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/1/76 |
| _version_ | 1797343027024363520 |
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| author | Eun-Young Nam Su Hyun Choi Ji Hye Hwang |
| author_facet | Eun-Young Nam Su Hyun Choi Ji Hye Hwang |
| author_sort | Eun-Young Nam |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Korean and traditional Chinese medicine state that pyrite is effective for fracture treatment, but supporting clinical data are limited. This systematic review aimed to investigate the therapeutic role of Chinese patent medicine containing pyrite (CPMP) in clinical treatment for fractures. <i>Materials and Methods</i>: Seven electronic databases were searched using the keywords “pyrite”, “pyritum”, and “zirantong” between inception and December 2022, yielding 29 published clinical studies. Randomized controlled trials that included CPMP were considered eligible regardless of the fracture type. Quality assessment and meta-analysis of the included RCTs were also performed. <i>Results</i>: Most studies showed high heterogeneity (I<sup>2</sup> > 50%) and significant results (<i>p</i> < 0.05). Compared to the results of the control group, CPMP was more effective in terms of the primary outcome related to the efficacy rate, including the total effective rate, callus growth rate, bone union, and edema disappearance time (all <i>p</i> < 0.00001) and in terms of secondary outcomes related to pain reduction, namely pain intensity and pain disappearance time, than the control group (both <i>p</i> < 0.01). CPMP was more effective than the control group in terms of erythrocyte sedimentation rate (<i>p</i> < 0.01), hematocrit (<i>p</i> < 0.01), erythrocyte aggregation (<i>p</i> < 0.05), and plasma viscosity (<i>p</i> < 0.05). CPMP did not cause serious side effects, and the incidence of complications was significantly less than that in the control group. <i>Conclusions</i>: CPMP may be a safe and effective alternative treatment for fractures and may be beneficial in preventing postoperative complications, reducing pain, relieving symptoms, and accelerating healing. |
| first_indexed | 2024-03-08T10:41:43Z |
| format | Article |
| id | doaj.art-d8dd7f2fa4eb4a7ca3c7c8cf6a046140 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T10:41:43Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-d8dd7f2fa4eb4a7ca3c7c8cf6a0461402024-01-26T17:35:15ZengMDPI AGMedicina1010-660X1648-91442023-12-016017610.3390/medicina60010076Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-AnalysisEun-Young Nam0Su Hyun Choi1Ji Hye Hwang2Mimi Korean Medicine Clinic, Seoul 05616, Republic of KoreaCollege of Korean Medicine, Gachon University, Seongnam 13120, Republic of KoreaDepartment of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea<i>Background and Objectives</i>: Korean and traditional Chinese medicine state that pyrite is effective for fracture treatment, but supporting clinical data are limited. This systematic review aimed to investigate the therapeutic role of Chinese patent medicine containing pyrite (CPMP) in clinical treatment for fractures. <i>Materials and Methods</i>: Seven electronic databases were searched using the keywords “pyrite”, “pyritum”, and “zirantong” between inception and December 2022, yielding 29 published clinical studies. Randomized controlled trials that included CPMP were considered eligible regardless of the fracture type. Quality assessment and meta-analysis of the included RCTs were also performed. <i>Results</i>: Most studies showed high heterogeneity (I<sup>2</sup> > 50%) and significant results (<i>p</i> < 0.05). Compared to the results of the control group, CPMP was more effective in terms of the primary outcome related to the efficacy rate, including the total effective rate, callus growth rate, bone union, and edema disappearance time (all <i>p</i> < 0.00001) and in terms of secondary outcomes related to pain reduction, namely pain intensity and pain disappearance time, than the control group (both <i>p</i> < 0.01). CPMP was more effective than the control group in terms of erythrocyte sedimentation rate (<i>p</i> < 0.01), hematocrit (<i>p</i> < 0.01), erythrocyte aggregation (<i>p</i> < 0.05), and plasma viscosity (<i>p</i> < 0.05). CPMP did not cause serious side effects, and the incidence of complications was significantly less than that in the control group. <i>Conclusions</i>: CPMP may be a safe and effective alternative treatment for fractures and may be beneficial in preventing postoperative complications, reducing pain, relieving symptoms, and accelerating healing.https://www.mdpi.com/1648-9144/60/1/76Chinese patent medicinefracturepyritepyritumsystematic reviewmeta-analysis |
| spellingShingle | Eun-Young Nam Su Hyun Choi Ji Hye Hwang Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis Medicina Chinese patent medicine fracture pyrite pyritum systematic review meta-analysis |
| title | Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis |
| title_full | Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis |
| title_fullStr | Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis |
| title_short | Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis |
| title_sort | therapeutic efficacy of chinese patent medicine containing pyrite for fractures a systematic review and meta analysis |
| topic | Chinese patent medicine fracture pyrite pyritum systematic review meta-analysis |
| url | https://www.mdpi.com/1648-9144/60/1/76 |
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