Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS
Abstract Background The comparison of respiratory system compliance (Crs) between COVID and non-COVID ARDS patients has been the object of debate, but few studies have evaluated it when considering applied positive end expiratory pressure (PEEP), which is one of the known determinants of Crs itself....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-022-01930-0 |
| _version_ | 1828138442038444032 |
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| author | Federica Fusina Filippo Albani Serena Crisci Alessandro Morandi Francesca Tansini Rasula Beschi Antonio Rosano Giuseppe Natalini |
| author_facet | Federica Fusina Filippo Albani Serena Crisci Alessandro Morandi Francesca Tansini Rasula Beschi Antonio Rosano Giuseppe Natalini |
| author_sort | Federica Fusina |
| collection | DOAJ |
| description | Abstract Background The comparison of respiratory system compliance (Crs) between COVID and non-COVID ARDS patients has been the object of debate, but few studies have evaluated it when considering applied positive end expiratory pressure (PEEP), which is one of the known determinants of Crs itself. The aim of this study was to compare Crs taking into account the applied PEEP. Methods Two cohorts of patients were created: those with COVID-ARDS and those with non-COVID ARDS. In the whole sample the association between Crs and type of ARDS at different PEEP levels was adjusted for anthropometric and clinical variables. As secondary analyses, patients were matched for predicted functional residual capacity and the same association was assessed. Moreover, the association between Crs and type of ARDS was reassessed at predefined PEEP level of 0, 5, 10, and 15 cmH2O with a propensity score-weighted linear model. Results 367 patients were included in the study, 276 patients with COVID-ARDS and 91 with non-COVID ARDS. The association between Crs and type of ARDS was not significant in both the complete cohorts (p = 0.17) and in the matched cohorts (p = 0.92). This was true also for the propensity score weighted association at PEEP 5, 10 and 15 cmH2O, while it was statistically significant at PEEP 0 (with a median difference of 3 ml/cmH2O, which in our opinion is not clinically significant). Conclusions The compliance of the respiratory system is similar between COVID ARDS and non-COVID ARDS when calculated at the same PEEP level and while taking into account patients’ anthropometric characteristics. |
| first_indexed | 2024-04-11T18:35:53Z |
| format | Article |
| id | doaj.art-d8deaa9c6a4a4ba29a42bd45389d0a1f |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-11T18:35:53Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-d8deaa9c6a4a4ba29a42bd45389d0a1f2022-12-22T04:09:17ZengBMCRespiratory Research1465-993X2022-01-012311810.1186/s12931-022-01930-0Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDSFederica Fusina0Filippo Albani1Serena Crisci2Alessandro Morandi3Francesca Tansini4Rasula Beschi5Antonio Rosano6Giuseppe Natalini7Department of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalDepartment of Anesthesia, Intensive Care and Pain Medicine, Fondazione Poliambulanza HospitalAbstract Background The comparison of respiratory system compliance (Crs) between COVID and non-COVID ARDS patients has been the object of debate, but few studies have evaluated it when considering applied positive end expiratory pressure (PEEP), which is one of the known determinants of Crs itself. The aim of this study was to compare Crs taking into account the applied PEEP. Methods Two cohorts of patients were created: those with COVID-ARDS and those with non-COVID ARDS. In the whole sample the association between Crs and type of ARDS at different PEEP levels was adjusted for anthropometric and clinical variables. As secondary analyses, patients were matched for predicted functional residual capacity and the same association was assessed. Moreover, the association between Crs and type of ARDS was reassessed at predefined PEEP level of 0, 5, 10, and 15 cmH2O with a propensity score-weighted linear model. Results 367 patients were included in the study, 276 patients with COVID-ARDS and 91 with non-COVID ARDS. The association between Crs and type of ARDS was not significant in both the complete cohorts (p = 0.17) and in the matched cohorts (p = 0.92). This was true also for the propensity score weighted association at PEEP 5, 10 and 15 cmH2O, while it was statistically significant at PEEP 0 (with a median difference of 3 ml/cmH2O, which in our opinion is not clinically significant). Conclusions The compliance of the respiratory system is similar between COVID ARDS and non-COVID ARDS when calculated at the same PEEP level and while taking into account patients’ anthropometric characteristics.https://doi.org/10.1186/s12931-022-01930-0Respiratory systemRespirationArtificialIntensive care unitsPEEPVentilation |
| spellingShingle | Federica Fusina Filippo Albani Serena Crisci Alessandro Morandi Francesca Tansini Rasula Beschi Antonio Rosano Giuseppe Natalini Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS Respiratory Research Respiratory system Respiration Artificial Intensive care units PEEP Ventilation |
| title | Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS |
| title_full | Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS |
| title_fullStr | Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS |
| title_full_unstemmed | Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS |
| title_short | Respiratory system compliance at the same PEEP level is similar in COVID and non-COVID ARDS |
| title_sort | respiratory system compliance at the same peep level is similar in covid and non covid ards |
| topic | Respiratory system Respiration Artificial Intensive care units PEEP Ventilation |
| url | https://doi.org/10.1186/s12931-022-01930-0 |
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