Engineered extracellular vesicles in female reproductive disorders
Biologically active and nanoscale extracellular vesicles (EVs) participate in a variety of cellular physiological and pathological processes in a cell-free manner. Unlike cells, EVs not only do not cause acute immune rejection, but are much smaller and have a low risk of tumorigenicity or embolizati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223010752 |
| _version_ | 1797686895912681472 |
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| author | Mengxue Zhang Jie Xing Shijie Zhao Hui Chen Xinming Yin Xiaolan Zhu |
| author_facet | Mengxue Zhang Jie Xing Shijie Zhao Hui Chen Xinming Yin Xiaolan Zhu |
| author_sort | Mengxue Zhang |
| collection | DOAJ |
| description | Biologically active and nanoscale extracellular vesicles (EVs) participate in a variety of cellular physiological and pathological processes in a cell-free manner. Unlike cells, EVs not only do not cause acute immune rejection, but are much smaller and have a low risk of tumorigenicity or embolization. Because of their unique advantages, EVs show promise in applications in the diagnosis and treatment of reproductive disorders. As research broadens, engineering strategies for EVs have been developed, and engineering strategies for EVs have substantially improved their application potential while circumventing the defects of natural EVs, driving EVs toward clinical applications. In this paper, we will review the engineering strategies of EVs, as well as their regulatory effects and mechanisms on reproductive disorders (including premature ovarian insufficiency (POI), polycystic ovarian syndrome (PCOS), recurrent spontaneous abortion (RSA), intrauterine adhesion (IUA), and endometriosis (EMS)) and their application prospects. This work provides new ideas for the treatment of female reproductive disorders by engineering EVs. |
| first_indexed | 2024-03-12T01:12:13Z |
| format | Article |
| id | doaj.art-d8e0ce5ad24e41558f371b8dc4d9453c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:12:13Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-d8e0ce5ad24e41558f371b8dc4d9453c2023-09-14T04:52:30ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115284Engineered extracellular vesicles in female reproductive disordersMengxue Zhang0Jie Xing1Shijie Zhao2Hui Chen3Xinming Yin4Xiaolan Zhu5Reproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Institute of Reproductive Sciences, Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Department of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Institute of Reproductive Sciences, Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Department of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Institute of Reproductive Sciences, Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Department of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Institute of Reproductive Sciences, Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China; Corresponding author at: Reproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, PR China.Biologically active and nanoscale extracellular vesicles (EVs) participate in a variety of cellular physiological and pathological processes in a cell-free manner. Unlike cells, EVs not only do not cause acute immune rejection, but are much smaller and have a low risk of tumorigenicity or embolization. Because of their unique advantages, EVs show promise in applications in the diagnosis and treatment of reproductive disorders. As research broadens, engineering strategies for EVs have been developed, and engineering strategies for EVs have substantially improved their application potential while circumventing the defects of natural EVs, driving EVs toward clinical applications. In this paper, we will review the engineering strategies of EVs, as well as their regulatory effects and mechanisms on reproductive disorders (including premature ovarian insufficiency (POI), polycystic ovarian syndrome (PCOS), recurrent spontaneous abortion (RSA), intrauterine adhesion (IUA), and endometriosis (EMS)) and their application prospects. This work provides new ideas for the treatment of female reproductive disorders by engineering EVs.http://www.sciencedirect.com/science/article/pii/S0753332223010752Extracellular vesiclesNanotechnologyEngineered modificationFemale reproductive disorders |
| spellingShingle | Mengxue Zhang Jie Xing Shijie Zhao Hui Chen Xinming Yin Xiaolan Zhu Engineered extracellular vesicles in female reproductive disorders Biomedicine & Pharmacotherapy Extracellular vesicles Nanotechnology Engineered modification Female reproductive disorders |
| title | Engineered extracellular vesicles in female reproductive disorders |
| title_full | Engineered extracellular vesicles in female reproductive disorders |
| title_fullStr | Engineered extracellular vesicles in female reproductive disorders |
| title_full_unstemmed | Engineered extracellular vesicles in female reproductive disorders |
| title_short | Engineered extracellular vesicles in female reproductive disorders |
| title_sort | engineered extracellular vesicles in female reproductive disorders |
| topic | Extracellular vesicles Nanotechnology Engineered modification Female reproductive disorders |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223010752 |
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