Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia
Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer’s disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundam...
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2017.00389/full |
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| author | Soowon Park Taehoon Kim Seong A Shin Seong A Shin Yu Kyeong Kim Bo Kyung Sohn Hyeon-Ju Park Jung-Hae Youn Jun-Young Lee |
| author_facet | Soowon Park Taehoon Kim Seong A Shin Seong A Shin Yu Kyeong Kim Bo Kyung Sohn Hyeon-Ju Park Jung-Hae Youn Jun-Young Lee |
| author_sort | Soowon Park |
| collection | DOAJ |
| description | Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer’s disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in FER performance in patients with dementia.Purpose: The purpose of this study was to identify the performance profiles of six facial emotions (i.e., fear, anger, disgust, sadness, surprise, and happiness) and neutral faces measured among Korean healthy control (HCs), and those with mild cognitive impairment (MCI), AD, and FTD. Additionally, the neuroanatomical correlates of facial emotions were investigated.Methods: A total of 110 (33 HC, 32 MCI, 32 AD, 13 FTD) older adult participants were recruited from two different medical centers in metropolitan areas of South Korea. These individuals underwent an FER test that was used to assess the recognition of emotions or absence of emotion (neutral) in 35 facial stimuli. Repeated measures two-way analyses of variance were used to examine the distinct profiles of emotional recognition among the four groups. We also performed brain imaging and voxel-based morphometry (VBM) on the participants to examine the associations between FER scores and gray matter volume.Results: The mean score of negative emotion recognition (i.e., fear, anger, disgust, and sadness) clearly discriminated FTD participants from individuals with MCI and AD and HC [F(3,106) = 10.829, p < 0.001, η2 = 0.235], whereas the mean score of positive emotion recognition (i.e., surprise and happiness) did not. A VBM analysis showed negative emotions were correlated with gray matter volume of anterior temporal regions, whereas positive emotions were related to gray matter volume of fronto-parietal regions.Conclusion: Impairment of negative FER in patients with FTD is cross-cultural. The discrete neural correlates of FER indicate that emotional recognition processing is a multi-modal system in the brain. Focusing on the negative emotion recognition is a more effective way to discriminate healthy aging, MCI, and AD from FTD in older Korean adults. |
| first_indexed | 2024-12-17T08:10:04Z |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-17T08:10:04Z |
| publishDate | 2017-11-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d8e22745932c4f25b09e1d1097829d952022-12-21T21:57:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-11-01910.3389/fnagi.2017.00389282734Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal DementiaSoowon Park0Taehoon Kim1Seong A Shin2Seong A Shin3Yu Kyeong Kim4Bo Kyung Sohn5Hyeon-Ju Park6Jung-Hae Youn7Jun-Young Lee8Department of Education, Sejong University, Seoul, South KoreaDepartment of Psychiatry, Neuroscience Research Institute, Seoul National University and SMG-SNU Boramae Medical Center, Seoul, South KoreaDepartment of Biomedical Sciences, Seoul National University, Seoul, South KoreaDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South KoreaDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South KoreaDepartment of Psychiatry, Inje Univiersity Sanggye Paik Hospital, Seoul, South KoreaDepartment of Psychiatry, Neuroscience Research Institute, Seoul National University and SMG-SNU Boramae Medical Center, Seoul, South KoreaGraduate School of Clinical Counseling Psychology, CHA University, Pocheon, South KoreaDepartment of Psychiatry, Neuroscience Research Institute, Seoul National University and SMG-SNU Boramae Medical Center, Seoul, South KoreaBackground: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer’s disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in FER performance in patients with dementia.Purpose: The purpose of this study was to identify the performance profiles of six facial emotions (i.e., fear, anger, disgust, sadness, surprise, and happiness) and neutral faces measured among Korean healthy control (HCs), and those with mild cognitive impairment (MCI), AD, and FTD. Additionally, the neuroanatomical correlates of facial emotions were investigated.Methods: A total of 110 (33 HC, 32 MCI, 32 AD, 13 FTD) older adult participants were recruited from two different medical centers in metropolitan areas of South Korea. These individuals underwent an FER test that was used to assess the recognition of emotions or absence of emotion (neutral) in 35 facial stimuli. Repeated measures two-way analyses of variance were used to examine the distinct profiles of emotional recognition among the four groups. We also performed brain imaging and voxel-based morphometry (VBM) on the participants to examine the associations between FER scores and gray matter volume.Results: The mean score of negative emotion recognition (i.e., fear, anger, disgust, and sadness) clearly discriminated FTD participants from individuals with MCI and AD and HC [F(3,106) = 10.829, p < 0.001, η2 = 0.235], whereas the mean score of positive emotion recognition (i.e., surprise and happiness) did not. A VBM analysis showed negative emotions were correlated with gray matter volume of anterior temporal regions, whereas positive emotions were related to gray matter volume of fronto-parietal regions.Conclusion: Impairment of negative FER in patients with FTD is cross-cultural. The discrete neural correlates of FER indicate that emotional recognition processing is a multi-modal system in the brain. Focusing on the negative emotion recognition is a more effective way to discriminate healthy aging, MCI, and AD from FTD in older Korean adults.https://www.frontiersin.org/article/10.3389/fnagi.2017.00389/fullfacial emotion recognitionmild cognitive impairmentAlzheimer’s diseasefrontotemporal dementiavoxel-based morphometry |
| spellingShingle | Soowon Park Taehoon Kim Seong A Shin Seong A Shin Yu Kyeong Kim Bo Kyung Sohn Hyeon-Ju Park Jung-Hae Youn Jun-Young Lee Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia Frontiers in Aging Neuroscience facial emotion recognition mild cognitive impairment Alzheimer’s disease frontotemporal dementia voxel-based morphometry |
| title | Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia |
| title_full | Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia |
| title_fullStr | Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia |
| title_full_unstemmed | Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia |
| title_short | Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia |
| title_sort | behavioral and neuroimaging evidence for facial emotion recognition in elderly korean adults with mild cognitive impairment alzheimer s disease and frontotemporal dementia |
| topic | facial emotion recognition mild cognitive impairment Alzheimer’s disease frontotemporal dementia voxel-based morphometry |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2017.00389/full |
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