Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection
A 49-year-old male who had been working in welding for more than 30 years was admitted to the hospital for a medical checkup that revealed a lung shadow without specific symptoms such as coughing and sputum. Imaging studies showed diffuse ground-glass changes in both lungs, wall cavities with wall n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1001802/full |
| _version_ | 1797672385658224640 |
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| author | Yuli Zhou Ying Wang Wenbing Liu Haibin Wang Daqiang He Juan Jin Qiaoyun Li Junying Li Qiong Chen Senlin Ruan Shenghai Wu Jiyu Tang |
| author_facet | Yuli Zhou Ying Wang Wenbing Liu Haibin Wang Daqiang He Juan Jin Qiaoyun Li Junying Li Qiong Chen Senlin Ruan Shenghai Wu Jiyu Tang |
| author_sort | Yuli Zhou |
| collection | DOAJ |
| description | A 49-year-old male who had been working in welding for more than 30 years was admitted to the hospital for a medical checkup that revealed a lung shadow without specific symptoms such as coughing and sputum. Imaging studies showed diffuse ground-glass changes in both lungs, wall cavities with wall nodules, multiple peripheral nodules, and some nodules with calcification. The patient has been engaged in welding work for more than 30 years and exposed to iron dust. Lung tissue biopsy, routine morphological and pathological fluid basis examination of alveolar lavage fluid, can be considered as pulmonary iron particles, which can be regarded as iron dust lung. Acid-fast bacilli were detected in both fibrobronchoscopic brush extract and alveolar lavage fluid acid-fast staining. As the pathological examination revealed granulomatous inflammation showed caseation necrosis, the patient was judged to have concomitant pulmonary TB. After the diagnosis was made, the patient was no longer exposed to dust and was treated with appropriate anti- tuberculosis (TB) therapy. Lung lesions caused by welding have been reported, but the simultaneous finding of siderosis with pulmonary TB is specific to the case presented here. By describing the imaging features, combining different staining methods of alveolar lavage fluid and pathological examination of lung tissue, we showed various morphological manifestations of this case, aiming at improving the morphological diagnosis level of laboratory physicians and enabling patients to be diagnosed and treated early. |
| first_indexed | 2024-03-11T21:29:17Z |
| format | Article |
| id | doaj.art-d8e2739c47034b9da43ba58712d72b0c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T21:29:17Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d8e2739c47034b9da43ba58712d72b0c2023-09-27T11:47:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10018021001802Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infectionYuli Zhou0Ying Wang1Wenbing Liu2Haibin Wang3Daqiang He4Juan Jin5Qiaoyun Li6Junying Li7Qiong Chen8Senlin Ruan9Shenghai Wu10Jiyu Tang11Department of Laboratory, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory, Shenzhen Second People’s Hospital, Shenzhen, ChinaDepartment of Cardiopulmonary Medicine, Zhejiang Rehabilitation Medical Center, Hangzhou, ChinaDepartment of Radiology, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaHangzhou Medical College, Lin’an people’s Hospital, Hangzhou, ChinaDepartment of Pathology, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaAgricultural and Biological Ring Testing Center, Zhejiang University, Hangzhou, ChinaDepartment of Laboratory, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Nephrology, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaA 49-year-old male who had been working in welding for more than 30 years was admitted to the hospital for a medical checkup that revealed a lung shadow without specific symptoms such as coughing and sputum. Imaging studies showed diffuse ground-glass changes in both lungs, wall cavities with wall nodules, multiple peripheral nodules, and some nodules with calcification. The patient has been engaged in welding work for more than 30 years and exposed to iron dust. Lung tissue biopsy, routine morphological and pathological fluid basis examination of alveolar lavage fluid, can be considered as pulmonary iron particles, which can be regarded as iron dust lung. Acid-fast bacilli were detected in both fibrobronchoscopic brush extract and alveolar lavage fluid acid-fast staining. As the pathological examination revealed granulomatous inflammation showed caseation necrosis, the patient was judged to have concomitant pulmonary TB. After the diagnosis was made, the patient was no longer exposed to dust and was treated with appropriate anti- tuberculosis (TB) therapy. Lung lesions caused by welding have been reported, but the simultaneous finding of siderosis with pulmonary TB is specific to the case presented here. By describing the imaging features, combining different staining methods of alveolar lavage fluid and pathological examination of lung tissue, we showed various morphological manifestations of this case, aiming at improving the morphological diagnosis level of laboratory physicians and enabling patients to be diagnosed and treated early.https://www.frontiersin.org/articles/10.3389/fonc.2023.1001802/fullweldersiderosistuberculosismorphologycase report |
| spellingShingle | Yuli Zhou Ying Wang Wenbing Liu Haibin Wang Daqiang He Juan Jin Qiaoyun Li Junying Li Qiong Chen Senlin Ruan Shenghai Wu Jiyu Tang Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection Frontiers in Oncology welder siderosis tuberculosis morphology case report |
| title | Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection |
| title_full | Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection |
| title_fullStr | Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection |
| title_full_unstemmed | Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection |
| title_short | Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection |
| title_sort | case report application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection |
| topic | welder siderosis tuberculosis morphology case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1001802/full |
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