Differential pulse voltammetric determination of theophylline at poly(4-amino-3-hydroxyl naphthalene sulfonic acid) modified glassy carbon electrode
A glassy carbon electrode (GCE) was modified with electropolymerized film of 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) in 0.1 M HNO<sub>3</sub>. Cyclic voltammetry (CV) was used to study the electrochemical properties of the polymer film. The polymer film-modified electrode was...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2012-12-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://www.ajol.info/index.php/bcse/article/view/72962 |
| Summary: | A glassy carbon electrode (GCE) was modified with electropolymerized film of 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) in 0.1 M HNO<sub>3</sub>. Cyclic voltammetry (CV) was used to study the electrochemical properties of the polymer film. The polymer film-modified electrode was used to electrochemically detect theophylline (TP) in drug samples. The polymer-modified electrode showed excellent electrocatalytic activity for the oxidation of TP. Under optimal experimental conditions, there was a good linear relationship between anodic peak current and TP concentration in the range from 1.0 x 10<sup>-6</sup> to 1.0 x 10<sup>-4</sup> M with the correlation coefficient of 0.9983 and a detection limit of 4.7 x 10<sup>-8</sup> M (S/N = 3 for n = 6). The application of the polymer-modified GCE for the determination of TP in drug formulations showed good recovery and reproducible results.DOI: http://dx.doi.org/10.4314/bcse.v26i1.8 |
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| ISSN: | 1011-3924 1726-801X |