Co-aggregation of MSC/chondrocyte in a dynamic 3D culture elevates the therapeutic effect of secreted extracellular vesicles on osteoarthritis in a rat model

Abstract Extracellular vesicles (EVs) have therapeutic effects on osteoarthritis (OA). Some recent strategies could elevate EV's therapeutic properties including cell aggregation, co-culture, and 3D culture. It seems that a combination of these strategies could augment EV production and therape...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Abazar Esmaeili, Samaneh Hosseini, Amir Kamali, Maryam Hosseinzadeh, Faezeh Shekari, Mohamadreza Baghaban Eslaminejad
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Nature Portfolio 2022-11-01
Цуврал:Scientific Reports
Онлайн хандалт:https://doi.org/10.1038/s41598-022-22592-4