Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy
BackgroundThe survival rate of children and adolescents with acute lymphoblastic leukemia (ALL) has progressively improved. However, ALL survivors often have adverse effects after treatment, such as an increased risk of obesity. Obesity has been associated with reduced survival.ObjectiveWe investiga...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.797836/full |
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| author | Jing Sun Ru Zhang Jianjun Tang Xuedong Wu Lu Zhu Haiying Huang Huimin Chen Minhua Xiao Hongfeng Luo Haiqing Zheng Jiaqi Chen |
| author_facet | Jing Sun Ru Zhang Jianjun Tang Xuedong Wu Lu Zhu Haiying Huang Huimin Chen Minhua Xiao Hongfeng Luo Haiqing Zheng Jiaqi Chen |
| author_sort | Jing Sun |
| collection | DOAJ |
| description | BackgroundThe survival rate of children and adolescents with acute lymphoblastic leukemia (ALL) has progressively improved. However, ALL survivors often have adverse effects after treatment, such as an increased risk of obesity. Obesity has been associated with reduced survival.ObjectiveWe investigated the relationship between obesity, adipocytokine levels, and ALL short-term outcomes.MethodsWeight and height were measured, and body mass index (BMI) was calculated at patient diagnosis and discharge. Leptin and Adiponectin levels and Minimal Residual Disease (MRD) were measured before therapy, at days 19 of remission-induction therapy, and at the end of remission-induction therapy (days 46). The relationship between BMI, adipocytokine levels, and MRD was then determined.ResultsCompared to the normal BMI group, children with an abnormal increase in BMI had an increase in MRD at day 19 and 46 (P = 0.04 and P = 0.008), and showed a positive correlation (P = 0.014). In addition, we found a positive correlation between weight, hip circumference at diagnosis and at day 19, and MRD at day 46. Both BMI and fat concentric distribution affected the outcome of ALL children. A higher BMI was also associated with a significant increase in Leptin levels at diagnosis. Leptin resistance should be considered in ALL children with high BMI.ConclusionBMI affects the outcome of ALL patients. Early interventions such as regular weight, height monitoring, and dietary assessments should be preferably initiated during remission-induction chemotherapy. |
| first_indexed | 2024-12-18T10:55:04Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-18T10:55:04Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-d8e57e7e4376418d90c4928630ab00d02022-12-21T21:10:21ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-03-011010.3389/fped.2022.797836797836Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction ChemotherapyJing Sun0Ru Zhang1Jianjun Tang2Xuedong Wu3Lu Zhu4Haiying Huang5Huimin Chen6Minhua Xiao7Hongfeng Luo8Haiqing Zheng9Jiaqi Chen10Department of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaInstitute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, ChinaDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaBackgroundThe survival rate of children and adolescents with acute lymphoblastic leukemia (ALL) has progressively improved. However, ALL survivors often have adverse effects after treatment, such as an increased risk of obesity. Obesity has been associated with reduced survival.ObjectiveWe investigated the relationship between obesity, adipocytokine levels, and ALL short-term outcomes.MethodsWeight and height were measured, and body mass index (BMI) was calculated at patient diagnosis and discharge. Leptin and Adiponectin levels and Minimal Residual Disease (MRD) were measured before therapy, at days 19 of remission-induction therapy, and at the end of remission-induction therapy (days 46). The relationship between BMI, adipocytokine levels, and MRD was then determined.ResultsCompared to the normal BMI group, children with an abnormal increase in BMI had an increase in MRD at day 19 and 46 (P = 0.04 and P = 0.008), and showed a positive correlation (P = 0.014). In addition, we found a positive correlation between weight, hip circumference at diagnosis and at day 19, and MRD at day 46. Both BMI and fat concentric distribution affected the outcome of ALL children. A higher BMI was also associated with a significant increase in Leptin levels at diagnosis. Leptin resistance should be considered in ALL children with high BMI.ConclusionBMI affects the outcome of ALL patients. Early interventions such as regular weight, height monitoring, and dietary assessments should be preferably initiated during remission-induction chemotherapy.https://www.frontiersin.org/articles/10.3389/fped.2022.797836/fullchildhood acute lymphoblastic leukemiaremission-induction chemotherapyobesitybody mass indexminimal residual disease (MRD)adipocytokine |
| spellingShingle | Jing Sun Ru Zhang Jianjun Tang Xuedong Wu Lu Zhu Haiying Huang Huimin Chen Minhua Xiao Hongfeng Luo Haiqing Zheng Jiaqi Chen Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy Frontiers in Pediatrics childhood acute lymphoblastic leukemia remission-induction chemotherapy obesity body mass index minimal residual disease (MRD) adipocytokine |
| title | Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy |
| title_full | Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy |
| title_fullStr | Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy |
| title_full_unstemmed | Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy |
| title_short | Prognostic Observational Analysis of BMI, Leptin, and Adiponectin in Children With Acute Lymphocytic Leukemia Undergoing Remission-Induction Chemotherapy |
| title_sort | prognostic observational analysis of bmi leptin and adiponectin in children with acute lymphocytic leukemia undergoing remission induction chemotherapy |
| topic | childhood acute lymphoblastic leukemia remission-induction chemotherapy obesity body mass index minimal residual disease (MRD) adipocytokine |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.797836/full |
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