The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression.
BACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2626627?pdf=render |
| _version_ | 1818173663110758400 |
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| author | Sandra Dupouy Véronique Viardot-Foucault Marco Alifano Frédérique Souazé Geneviève Plu-Bureau Marc Chaouat Anne Lavaur Danielle Hugol Christian Gespach Anne Gompel Patricia Forgez |
| author_facet | Sandra Dupouy Véronique Viardot-Foucault Marco Alifano Frédérique Souazé Geneviève Plu-Bureau Marc Chaouat Anne Lavaur Danielle Hugol Christian Gespach Anne Gompel Patricia Forgez |
| author_sort | Sandra Dupouy |
| collection | DOAJ |
| description | BACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion. METHODS AND RESULTS: we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients. CONCLUSION: these data support the activation of neurotensinergic deleterious pathways in breast cancer progression. |
| first_indexed | 2024-12-11T19:32:05Z |
| format | Article |
| id | doaj.art-d8e6396fd3c64e169f638baea5c72ad3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T19:32:05Z |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d8e6396fd3c64e169f638baea5c72ad32022-12-22T00:53:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0141e422310.1371/journal.pone.0004223The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression.Sandra DupouyVéronique Viardot-FoucaultMarco AlifanoFrédérique SouazéGeneviève Plu-BureauMarc ChaouatAnne LavaurDanielle HugolChristian GespachAnne GompelPatricia ForgezBACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion. METHODS AND RESULTS: we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients. CONCLUSION: these data support the activation of neurotensinergic deleterious pathways in breast cancer progression.http://europepmc.org/articles/PMC2626627?pdf=render |
| spellingShingle | Sandra Dupouy Véronique Viardot-Foucault Marco Alifano Frédérique Souazé Geneviève Plu-Bureau Marc Chaouat Anne Lavaur Danielle Hugol Christian Gespach Anne Gompel Patricia Forgez The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. PLoS ONE |
| title | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. |
| title_full | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. |
| title_fullStr | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. |
| title_full_unstemmed | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. |
| title_short | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. |
| title_sort | neurotensin receptor 1 pathway contributes to human ductal breast cancer progression |
| url | http://europepmc.org/articles/PMC2626627?pdf=render |
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