Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study
Abstract Purpose The prevalence of atopic diseases has increased in recent decades. A possible link between antibiotic use during pregnancy and childhood atopic disease has been proposed. The aim of this study is to explore the association of antibiotic exposure during pregnancy with childhood atopi...
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| Formato: | Artigo |
| Idioma: | English |
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BMC
2024-03-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Acceso en liña: | https://doi.org/10.1186/s40001-024-01793-9 |
| _version_ | 1827310365345579008 |
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| author | Sheng-Kang Tai Yi-Hsuan Lin Ching-Heng Lin Ming-Chih Lin |
| author_facet | Sheng-Kang Tai Yi-Hsuan Lin Ching-Heng Lin Ming-Chih Lin |
| author_sort | Sheng-Kang Tai |
| collection | DOAJ |
| description | Abstract Purpose The prevalence of atopic diseases has increased in recent decades. A possible link between antibiotic use during pregnancy and childhood atopic disease has been proposed. The aim of this study is to explore the association of antibiotic exposure during pregnancy with childhood atopic diseases from a nationwide, population-based perspective. Methods This was a nationwide population-based cohort study. Taiwan’s National Health Insurance Research Database was the main source of data. The pairing of mothers and children was achieved by linking the NHIRD with the Taiwan Maternal and Child Health Database. This study enrolled the first-time pregnancies from 2004 to 2010. Infants of multiple delivery, preterm delivery, and death before 5 years old were excluded. All participants were followed up at least for 5 years. Antenatal antibiotics prescribed to mothers during the pregnancy period were reviewed. Children with more than two outpatient visits, or one admission, with a main diagnosis of asthma, allergic rhinitis, or atopic dermatitis were regarded as having an atopic disease. Results A total of 900,584 children were enrolled in this study. The adjusted hazard ratios of antibiotic exposure during pregnancy to childhood atopic diseases were 1.12 for atopic dermatitis, 1.06 for asthma, and 1.08 for allergic rhinitis, all of which reached statistical significance. The trimester effect was not significant. There was a trend showing the higher the number of times a child was prenatally exposed to antibiotics, the higher the hazard ratio was for childhood atopic diseases. Conclusions Prenatal antibiotic exposure might increase the risk of childhood atopic diseases in a dose-dependent manner. |
| first_indexed | 2024-04-24T19:58:36Z |
| format | Article |
| id | doaj.art-d8e64c98fcbb4129888584201923741e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-24T19:58:36Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-d8e64c98fcbb4129888584201923741e2024-03-24T12:14:11ZengBMCEuropean Journal of Medical Research2047-783X2024-03-0129111110.1186/s40001-024-01793-9Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort studySheng-Kang Tai0Yi-Hsuan Lin1Ching-Heng Lin2Ming-Chih Lin3Department of Pediatrics, Show Chwan Memorial HospitalChildren’s Medical Center, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalChildren’s Medical Center, Taichung Veterans General HospitalAbstract Purpose The prevalence of atopic diseases has increased in recent decades. A possible link between antibiotic use during pregnancy and childhood atopic disease has been proposed. The aim of this study is to explore the association of antibiotic exposure during pregnancy with childhood atopic diseases from a nationwide, population-based perspective. Methods This was a nationwide population-based cohort study. Taiwan’s National Health Insurance Research Database was the main source of data. The pairing of mothers and children was achieved by linking the NHIRD with the Taiwan Maternal and Child Health Database. This study enrolled the first-time pregnancies from 2004 to 2010. Infants of multiple delivery, preterm delivery, and death before 5 years old were excluded. All participants were followed up at least for 5 years. Antenatal antibiotics prescribed to mothers during the pregnancy period were reviewed. Children with more than two outpatient visits, or one admission, with a main diagnosis of asthma, allergic rhinitis, or atopic dermatitis were regarded as having an atopic disease. Results A total of 900,584 children were enrolled in this study. The adjusted hazard ratios of antibiotic exposure during pregnancy to childhood atopic diseases were 1.12 for atopic dermatitis, 1.06 for asthma, and 1.08 for allergic rhinitis, all of which reached statistical significance. The trimester effect was not significant. There was a trend showing the higher the number of times a child was prenatally exposed to antibiotics, the higher the hazard ratio was for childhood atopic diseases. Conclusions Prenatal antibiotic exposure might increase the risk of childhood atopic diseases in a dose-dependent manner.https://doi.org/10.1186/s40001-024-01793-9Allergic rhinitisAntibioticsAsthmaAtopic dermatitisPrenatal exposure |
| spellingShingle | Sheng-Kang Tai Yi-Hsuan Lin Ching-Heng Lin Ming-Chih Lin Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study European Journal of Medical Research Allergic rhinitis Antibiotics Asthma Atopic dermatitis Prenatal exposure |
| title | Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study |
| title_full | Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study |
| title_fullStr | Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study |
| title_full_unstemmed | Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study |
| title_short | Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study |
| title_sort | antibiotic exposure during pregnancy increases risk for childhood atopic diseases a nationwide cohort study |
| topic | Allergic rhinitis Antibiotics Asthma Atopic dermatitis Prenatal exposure |
| url | https://doi.org/10.1186/s40001-024-01793-9 |
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