Identification and Characterization of New <i>Alu</i> Element Insertion in the <i>BRCA1</i> Exon 14 Associated with Hereditary Breast and Ovarian Cancer

Identification and Characterization of New <i>Alu</i> Element Insertion in the <i>BRCA1</i> Exon 14 Associated with Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer syndrome (HBOC) is an autosomal dominant cancer predisposition syndrome characterized by an increased risk of breast and ovarian cancers. Germline pathogenic variants in <i>BRCA1</i> are found in about 7–10% of all familial breast cancers and 10% of o...

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Bibliographic Details
Main Authors: Ahmed Bouras, Melanie Leone, Valerie Bonadona, Marine Lebrun, Alain Calender, Nadia Boutry-Kryza
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Genes
Subjects:
hereditary breast and ovarian cancer
next-generation sequencing
<i>BRCA1</i>
<i>Alu</i>Yb8
retrotransposon
Online Access:https://www.mdpi.com/2073-4425/12/11/1736

Internet

https://www.mdpi.com/2073-4425/12/11/1736

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