Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer
Cancer and neurodegenerative disorders present overwhelming challenges for healthcare worldwide. Epidemiological studies showed a decrease in cancer rates in patients with neurodegenerative disorders, including the Huntington disease (HD). Apoptosis is one of the most important processes for both ca...
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| author | Elena Yu. Bragina Densema E. Gomboeva Olga V. Saik Vladimir A. Ivanisenko Maxim B. Freidin Maria S. Nazarenko Valery P. Puzyrev |
| author_facet | Elena Yu. Bragina Densema E. Gomboeva Olga V. Saik Vladimir A. Ivanisenko Maxim B. Freidin Maria S. Nazarenko Valery P. Puzyrev |
| author_sort | Elena Yu. Bragina |
| collection | DOAJ |
| description | Cancer and neurodegenerative disorders present overwhelming challenges for healthcare worldwide. Epidemiological studies showed a decrease in cancer rates in patients with neurodegenerative disorders, including the Huntington disease (HD). Apoptosis is one of the most important processes for both cancer and neurodegeneration. We suggest that genes closely connected with apoptosis and associated with HD may affect carcinogenesis. We applied reconstruction and analysis of gene networks associated with HD and apoptosis and identified potentially important genes for inverse comorbidity of cancer and HD. The top 10 high-priority candidate genes included <i>APOE</i>, <i>PSEN1</i>, <i>INS</i>, <i>IL6</i>, <i>SQSTM1</i>, <i>SP1</i>, <i>HTT</i>, <i>LEP</i>, <i>HSPA4</i>, and <i>BDNF.</i> Functional analysis of these genes was carried out using gene ontology and KEGG pathways. By exploring genome-wide association study results, we identified genes associated with neurodegenerative and oncological disorders, as well as their endophenotypes and risk factors. We used publicly available datasets of HD and breast and prostate cancers to analyze the expression of the identified genes. Functional modules of these genes were characterized according to disease-specific tissues. This integrative approach revealed that these genes predominantly exert similar functions in different tissues. Apoptosis along with lipid metabolism dysregulation and cell homeostasis maintenance in the response to environmental stimulus and drugs are likely key processes in inverse comorbidity of cancer in patients with HD. Overall, the identified genes represent the promising targets for studying molecular relations of cancer and HD. |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d8e959d39ece4e4a95d91549b7fbcd6c2023-11-18T07:58:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411938510.3390/ijms24119385Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and CancerElena Yu. Bragina0Densema E. Gomboeva1Olga V. Saik2Vladimir A. Ivanisenko3Maxim B. Freidin4Maria S. Nazarenko5Valery P. Puzyrev6Research Institute of Medical Genetics, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634050 Tomsk, RussiaResearch Institute of Medical Genetics, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634050 Tomsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaResearch Institute of Medical Genetics, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634050 Tomsk, RussiaResearch Institute of Medical Genetics, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634050 Tomsk, RussiaResearch Institute of Medical Genetics, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634050 Tomsk, RussiaCancer and neurodegenerative disorders present overwhelming challenges for healthcare worldwide. Epidemiological studies showed a decrease in cancer rates in patients with neurodegenerative disorders, including the Huntington disease (HD). Apoptosis is one of the most important processes for both cancer and neurodegeneration. We suggest that genes closely connected with apoptosis and associated with HD may affect carcinogenesis. We applied reconstruction and analysis of gene networks associated with HD and apoptosis and identified potentially important genes for inverse comorbidity of cancer and HD. The top 10 high-priority candidate genes included <i>APOE</i>, <i>PSEN1</i>, <i>INS</i>, <i>IL6</i>, <i>SQSTM1</i>, <i>SP1</i>, <i>HTT</i>, <i>LEP</i>, <i>HSPA4</i>, and <i>BDNF.</i> Functional analysis of these genes was carried out using gene ontology and KEGG pathways. By exploring genome-wide association study results, we identified genes associated with neurodegenerative and oncological disorders, as well as their endophenotypes and risk factors. We used publicly available datasets of HD and breast and prostate cancers to analyze the expression of the identified genes. Functional modules of these genes were characterized according to disease-specific tissues. This integrative approach revealed that these genes predominantly exert similar functions in different tissues. Apoptosis along with lipid metabolism dysregulation and cell homeostasis maintenance in the response to environmental stimulus and drugs are likely key processes in inverse comorbidity of cancer in patients with HD. Overall, the identified genes represent the promising targets for studying molecular relations of cancer and HD.https://www.mdpi.com/1422-0067/24/11/9385inverse comorbiditydystropyHuntington’s diseaseneurodegenerative diseaseapoptosiscancer |
| spellingShingle | Elena Yu. Bragina Densema E. Gomboeva Olga V. Saik Vladimir A. Ivanisenko Maxim B. Freidin Maria S. Nazarenko Valery P. Puzyrev Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer International Journal of Molecular Sciences inverse comorbidity dystropy Huntington’s disease neurodegenerative disease apoptosis cancer |
| title | Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer |
| title_full | Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer |
| title_fullStr | Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer |
| title_full_unstemmed | Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer |
| title_short | Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer |
| title_sort | apoptosis genes as a key to identification of inverse comorbidity of huntington s disease and cancer |
| topic | inverse comorbidity dystropy Huntington’s disease neurodegenerative disease apoptosis cancer |
| url | https://www.mdpi.com/1422-0067/24/11/9385 |
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