B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma
Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells’ signaling in pSS pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/8385 |
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| author | Leila Mohammadnezhad Mojtaba Shekarkar Azgomi Marco Pio La Manna Giuliana Guggino Cirino Botta Francesco Dieli Nadia Caccamo |
| author_facet | Leila Mohammadnezhad Mojtaba Shekarkar Azgomi Marco Pio La Manna Giuliana Guggino Cirino Botta Francesco Dieli Nadia Caccamo |
| author_sort | Leila Mohammadnezhad |
| collection | DOAJ |
| description | Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells’ signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells’ signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting <i>CD79A</i>, <i>CD79B</i>, and <i>LAMTOR4</i> as the shared genes can provide novel biomarkers for pSS progression into lymphoma. |
| first_indexed | 2024-03-11T04:16:35Z |
| format | Article |
| id | doaj.art-d8e9e33d38b5463cbc7d89fb9f34a472 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:16:35Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d8e9e33d38b5463cbc7d89fb9f34a4722023-11-17T23:08:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-01249838510.3390/ijms24098385B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell LymphomaLeila Mohammadnezhad0Mojtaba Shekarkar Azgomi1Marco Pio La Manna2Giuliana Guggino3Cirino Botta4Francesco Dieli5Nadia Caccamo6Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP Paolo Giaccone, 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP Paolo Giaccone, 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP Paolo Giaccone, 90127 Palermo, ItalyDepartment of Sciences for Health Promotion and Mother-Child Care “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Sciences for Health Promotion and Mother-Child Care “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP Paolo Giaccone, 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), AOUP Paolo Giaccone, 90127 Palermo, ItalyPrimary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells’ signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells’ signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting <i>CD79A</i>, <i>CD79B</i>, and <i>LAMTOR4</i> as the shared genes can provide novel biomarkers for pSS progression into lymphoma.https://www.mdpi.com/1422-0067/24/9/8385primary Sjogren syndromenon-hodgkins lymphomaDLBCLcell signalingBCR |
| spellingShingle | Leila Mohammadnezhad Mojtaba Shekarkar Azgomi Marco Pio La Manna Giuliana Guggino Cirino Botta Francesco Dieli Nadia Caccamo B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma International Journal of Molecular Sciences primary Sjogren syndrome non-hodgkins lymphoma DLBCL cell signaling BCR |
| title | B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma |
| title_full | B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma |
| title_fullStr | B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma |
| title_full_unstemmed | B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma |
| title_short | B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma |
| title_sort | b cell receptor signaling is thought to be a bridge between primary sjogren syndrome and diffuse large b cell lymphoma |
| topic | primary Sjogren syndrome non-hodgkins lymphoma DLBCL cell signaling BCR |
| url | https://www.mdpi.com/1422-0067/24/9/8385 |
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