Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons.

Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus and adversely affects the patients' quality of life. Evidence has accumulated that PDN is associated with hyperexcitability of peripheral nociceptive primary sensory neurons. However, the precise cellular mechanism...

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Bibliographic Details
Main Authors: Wei Sun, Bei Miao, Xiu-Chao Wang, Jian-Hong Duan, Xin Ye, Wen-Juan Han, Wen-Ting Wang, Ceng Luo, San-Jue Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3382466?pdf=render