Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT?
PURPOSEThe aim of this study was to compare 18F-fluorodeoxyglucose positron emission tomography– computed tomography (18F-FDG PET/CT) scan with computed tomography (CT) scan for detecting recurrence and metastasis in renal cell carcinoma patients.METHODSThis retrospective study included patients fro...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-09-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/role-of-18f-fdg-pet-ct-for-detection-of-recurrence/53637
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| _version_ | 1797691387582349312 |
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| author | Melvika Pereira Chirag B. Punatar Natasha Singh Sharad N. Sagade |
| author_facet | Melvika Pereira Chirag B. Punatar Natasha Singh Sharad N. Sagade |
| author_sort | Melvika Pereira |
| collection | DOAJ |
| description | PURPOSEThe aim of this study was to compare 18F-fluorodeoxyglucose positron emission tomography– computed tomography (18F-FDG PET/CT) scan with computed tomography (CT) scan for detecting recurrence and metastasis in renal cell carcinoma patients.METHODSThis retrospective study included patients from October 2013 to April 2017. Contrast-enhanced CT and PET/CT scans were compared and correlated with histopathology or/and follow-up studies.RESULTSSeventy-six patients, 60 males, were included. Lesions included primary renal, recurrent renal fossa lesions, lymph nodes, and distant metastatic lesions. Of 176 malignant lesions, CT detected 157 lesions; of which, 154 were true positive. Twenty-two false-negative lesions showed abnormal FDG uptake. CT scan had positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity, and accuracy of 98.0%, 37.1%, 87.5%, 81.2%, and 86.9%, respectively. All 176 lesions were PET/CT-positive. PET/CT had PPV, NPV, sensitivity, specificity, and accuracy of 100% each. The specificity and NPV of PET/CT were superior (P < .05).CONCLUSIONPET/CT appears more accurate than CT scan for detecting metastasis and recurrence in renal cell carcinoma patients. |
| first_indexed | 2024-03-12T02:13:34Z |
| format | Article |
| id | doaj.art-d8ebb2ce9b784e11b2adf2bdbba5b096 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:13:34Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-d8ebb2ce9b784e11b2adf2bdbba5b0962023-09-06T12:05:45ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122022-09-0128549850210.5152/dir.2022.2109613049054Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT?Melvika Pereira0Chirag B. Punatar1Natasha Singh2Sharad N. Sagade3 Department of Nuclear Medicine, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India Department of Urology, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India Department of Nuclear Medicine, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India Department of Urology, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India PURPOSEThe aim of this study was to compare 18F-fluorodeoxyglucose positron emission tomography– computed tomography (18F-FDG PET/CT) scan with computed tomography (CT) scan for detecting recurrence and metastasis in renal cell carcinoma patients.METHODSThis retrospective study included patients from October 2013 to April 2017. Contrast-enhanced CT and PET/CT scans were compared and correlated with histopathology or/and follow-up studies.RESULTSSeventy-six patients, 60 males, were included. Lesions included primary renal, recurrent renal fossa lesions, lymph nodes, and distant metastatic lesions. Of 176 malignant lesions, CT detected 157 lesions; of which, 154 were true positive. Twenty-two false-negative lesions showed abnormal FDG uptake. CT scan had positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity, and accuracy of 98.0%, 37.1%, 87.5%, 81.2%, and 86.9%, respectively. All 176 lesions were PET/CT-positive. PET/CT had PPV, NPV, sensitivity, specificity, and accuracy of 100% each. The specificity and NPV of PET/CT were superior (P < .05).CONCLUSIONPET/CT appears more accurate than CT scan for detecting metastasis and recurrence in renal cell carcinoma patients. http://www.dirjournal.org/archives/archive-detail/article-preview/role-of-18f-fdg-pet-ct-for-detection-of-recurrence/53637 |
| spellingShingle | Melvika Pereira Chirag B. Punatar Natasha Singh Sharad N. Sagade Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT? Diagnostic and Interventional Radiology |
| title | Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT? |
| title_full | Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT? |
| title_fullStr | Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT? |
| title_full_unstemmed | Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT? |
| title_short | Role of 18F-FDG PET/CT for detection of recurrence and metastases in renal cell carcinoma—are we underusing PET/CT? |
| title_sort | role of 18f fdg pet ct for detection of recurrence and metastases in renal cell carcinoma are we underusing pet ct |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/role-of-18f-fdg-pet-ct-for-detection-of-recurrence/53637
|
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