Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study
Introduction: Patients with gallstone disease have already been investigated for the prevalence of previously undetected thyroid dysfunction, and the findings point to a possible link between hypothyroidism and gallstone disease. This research was carried out to support the need for assessment o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/18510/63835_CE[Ra1]_F(IS)_QC(SD_IS)_PF1(AG_SL)_PFA(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: Patients with gallstone disease have already
been investigated for the prevalence of previously undetected
thyroid dysfunction, and the findings point to a possible link
between hypothyroidism and gallstone disease. This research
was carried out to support the need for assessment of the
thyroid status in patients presenting with gallstones.
Aim: To determine the prevalence of thyroid disorders and
to study the relationship between thyroid dysfunction and
sociodemographic variables in patients with gallstone disease.
Materials and Methods: A cross-sectional, observational, hospitalbased study was carried out at Geetanjali Medical College and
Hospital, Udaipur, Rajasthan, India, in 117 patients with gallstones
from January 2021 to June 2022. The sampling method was
consecutive sampling. Standard baseline investigations and thyroid
profiles were conducted. Operative and perioperative factors such
as age (ranging from 18-80 years), sex, co-morbidities, radiological
findings (number and size of stones, presence of Common Bile
Duct (CBD) stones), thyroid profile, surgeries performed, and
significance (p-value) of these factors were assessed based on
the Chi-square test.
Results: The mean age of participants was 44 years. There
were 37 (68%) males and 80 (32%) females. Of the 117 patients,
49 patients (41.9%) were found to have hypothyroidism, and
the remaining 68 patients (58.1%) were euthyroid. Among
these 49 patients, only 15 were known to have hypothyroidism,
while the remaining 34 patients were newly diagnosed. Of the
49 patients, 30 were females and 19 were males. There was
no significant association between hypothyroid state and
gallstone formation in either males (p-value: 0.154) or females
(p-value: 0.194).
Conclusion: A low prevalence of hypothyroidism was observed
in both sexes. Further large population studies are needed to
compare these findings. |
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| ISSN: | 2249-782X 0973-709X |