Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study
Introduction: Patients with gallstone disease have already been investigated for the prevalence of previously undetected thyroid dysfunction, and the findings point to a possible link between hypothyroidism and gallstone disease. This research was carried out to support the need for assessment o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-10-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/18510/63835_CE[Ra1]_F(IS)_QC(SD_IS)_PF1(AG_SL)_PFA(AG_KM)_PN(KM).pdf |
| _version_ | 1827788007143374848 |
|---|---|
| author | Chinmay Dangi Nilesh Mehta Mitkumar V Patel Urmilkumar Labana Yashasvi Patel Darshit Dineshbhai Patel Mohit Bimalbhai Goswami Ajay Chauhan |
| author_facet | Chinmay Dangi Nilesh Mehta Mitkumar V Patel Urmilkumar Labana Yashasvi Patel Darshit Dineshbhai Patel Mohit Bimalbhai Goswami Ajay Chauhan |
| author_sort | Chinmay Dangi |
| collection | DOAJ |
| description | Introduction: Patients with gallstone disease have already
been investigated for the prevalence of previously undetected
thyroid dysfunction, and the findings point to a possible link
between hypothyroidism and gallstone disease. This research
was carried out to support the need for assessment of the
thyroid status in patients presenting with gallstones.
Aim: To determine the prevalence of thyroid disorders and
to study the relationship between thyroid dysfunction and
sociodemographic variables in patients with gallstone disease.
Materials and Methods: A cross-sectional, observational, hospitalbased study was carried out at Geetanjali Medical College and
Hospital, Udaipur, Rajasthan, India, in 117 patients with gallstones
from January 2021 to June 2022. The sampling method was
consecutive sampling. Standard baseline investigations and thyroid
profiles were conducted. Operative and perioperative factors such
as age (ranging from 18-80 years), sex, co-morbidities, radiological
findings (number and size of stones, presence of Common Bile
Duct (CBD) stones), thyroid profile, surgeries performed, and
significance (p-value) of these factors were assessed based on
the Chi-square test.
Results: The mean age of participants was 44 years. There
were 37 (68%) males and 80 (32%) females. Of the 117 patients,
49 patients (41.9%) were found to have hypothyroidism, and
the remaining 68 patients (58.1%) were euthyroid. Among
these 49 patients, only 15 were known to have hypothyroidism,
while the remaining 34 patients were newly diagnosed. Of the
49 patients, 30 were females and 19 were males. There was
no significant association between hypothyroid state and
gallstone formation in either males (p-value: 0.154) or females
(p-value: 0.194).
Conclusion: A low prevalence of hypothyroidism was observed
in both sexes. Further large population studies are needed to
compare these findings. |
| first_indexed | 2024-03-11T17:00:46Z |
| format | Article |
| id | doaj.art-d8ef6f0f8bf244d8ae5e80935ace9dc0 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-11T17:00:46Z |
| publishDate | 2023-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-d8ef6f0f8bf244d8ae5e80935ace9dc02023-10-20T10:31:11ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-10-011710010310.7860/JCDR/2023/63835.18510Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional StudyChinmay Dangi0Nilesh Mehta1Mitkumar V Patel2Urmilkumar Labana3Yashasvi Patel4Darshit Dineshbhai Patel5Mohit Bimalbhai Goswami6Ajay Chauhan7Postgraduate Student, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Associate Professor, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Assistant Professor, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Senior Resident, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Assistant Professor, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Postgraduate Student, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Postgraduate Student, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Professor, Department of General Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Introduction: Patients with gallstone disease have already been investigated for the prevalence of previously undetected thyroid dysfunction, and the findings point to a possible link between hypothyroidism and gallstone disease. This research was carried out to support the need for assessment of the thyroid status in patients presenting with gallstones. Aim: To determine the prevalence of thyroid disorders and to study the relationship between thyroid dysfunction and sociodemographic variables in patients with gallstone disease. Materials and Methods: A cross-sectional, observational, hospitalbased study was carried out at Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India, in 117 patients with gallstones from January 2021 to June 2022. The sampling method was consecutive sampling. Standard baseline investigations and thyroid profiles were conducted. Operative and perioperative factors such as age (ranging from 18-80 years), sex, co-morbidities, radiological findings (number and size of stones, presence of Common Bile Duct (CBD) stones), thyroid profile, surgeries performed, and significance (p-value) of these factors were assessed based on the Chi-square test. Results: The mean age of participants was 44 years. There were 37 (68%) males and 80 (32%) females. Of the 117 patients, 49 patients (41.9%) were found to have hypothyroidism, and the remaining 68 patients (58.1%) were euthyroid. Among these 49 patients, only 15 were known to have hypothyroidism, while the remaining 34 patients were newly diagnosed. Of the 49 patients, 30 were females and 19 were males. There was no significant association between hypothyroid state and gallstone formation in either males (p-value: 0.154) or females (p-value: 0.194). Conclusion: A low prevalence of hypothyroidism was observed in both sexes. Further large population studies are needed to compare these findings.https://jcdr.net/articles/PDF/18510/63835_CE[Ra1]_F(IS)_QC(SD_IS)_PF1(AG_SL)_PFA(AG_KM)_PN(KM).pdfcholedocholithiasischolelithiasishypothyroidismsphincter of oddi dysfunctionsubclinical hypothyroidism |
| spellingShingle | Chinmay Dangi Nilesh Mehta Mitkumar V Patel Urmilkumar Labana Yashasvi Patel Darshit Dineshbhai Patel Mohit Bimalbhai Goswami Ajay Chauhan Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study Journal of Clinical and Diagnostic Research choledocholithiasis cholelithiasis hypothyroidism sphincter of oddi dysfunction subclinical hypothyroidism |
| title | Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study |
| title_full | Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study |
| title_fullStr | Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study |
| title_full_unstemmed | Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study |
| title_short | Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study |
| title_sort | prevalence of thyroid dysfunction in patients with gallstone disease a cross sectional study |
| topic | choledocholithiasis cholelithiasis hypothyroidism sphincter of oddi dysfunction subclinical hypothyroidism |
| url | https://jcdr.net/articles/PDF/18510/63835_CE[Ra1]_F(IS)_QC(SD_IS)_PF1(AG_SL)_PFA(AG_KM)_PN(KM).pdf |
| work_keys_str_mv | AT chinmaydangi prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT nileshmehta prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT mitkumarvpatel prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT urmilkumarlabana prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT yashasvipatel prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT darshitdineshbhaipatel prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT mohitbimalbhaigoswami prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy AT ajaychauhan prevalenceofthyroiddysfunctioninpatientswithgallstonediseaseacrosssectionalstudy |