S100A9 extends lifespan in insulin deficiency
Insulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid homeostasis and extends survival in insulin defici...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11498-x |
| _version_ | 1819036155446820864 |
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| author | Giorgio Ramadori Sanda Ljubicic Serena Ricci Despoina Mikropoulou Xavier Brenachot Christelle Veyrat-Durebex Ebru Aras Rafael M. Ioris Jordi Altirriba Elisabeth Malle Dirk Foell Thomas Vogl Roberto Coppari |
| author_facet | Giorgio Ramadori Sanda Ljubicic Serena Ricci Despoina Mikropoulou Xavier Brenachot Christelle Veyrat-Durebex Ebru Aras Rafael M. Ioris Jordi Altirriba Elisabeth Malle Dirk Foell Thomas Vogl Roberto Coppari |
| author_sort | Giorgio Ramadori |
| collection | DOAJ |
| description | Insulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid homeostasis and extends survival in insulin deficient mice. |
| first_indexed | 2024-12-21T08:01:02Z |
| format | Article |
| id | doaj.art-d8ef89e1a35d49b49dd4c3ecbbce6524 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T08:01:02Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d8ef89e1a35d49b49dd4c3ecbbce65242022-12-21T19:10:54ZengNature PortfolioNature Communications2041-17232019-08-0110111210.1038/s41467-019-11498-xS100A9 extends lifespan in insulin deficiencyGiorgio Ramadori0Sanda Ljubicic1Serena Ricci2Despoina Mikropoulou3Xavier Brenachot4Christelle Veyrat-Durebex5Ebru Aras6Rafael M. Ioris7Jordi Altirriba8Elisabeth Malle9Dirk Foell10Thomas Vogl11Roberto Coppari12Diabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDiabetes Center of the Faculty of Medicine, University of GenevaDepartment of Pediatric Rheumatology and Immunology, University of MunsterInstitute of Immunology, University of MunsterDiabetes Center of the Faculty of Medicine, University of GenevaInsulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid homeostasis and extends survival in insulin deficient mice.https://doi.org/10.1038/s41467-019-11498-x |
| spellingShingle | Giorgio Ramadori Sanda Ljubicic Serena Ricci Despoina Mikropoulou Xavier Brenachot Christelle Veyrat-Durebex Ebru Aras Rafael M. Ioris Jordi Altirriba Elisabeth Malle Dirk Foell Thomas Vogl Roberto Coppari S100A9 extends lifespan in insulin deficiency Nature Communications |
| title | S100A9 extends lifespan in insulin deficiency |
| title_full | S100A9 extends lifespan in insulin deficiency |
| title_fullStr | S100A9 extends lifespan in insulin deficiency |
| title_full_unstemmed | S100A9 extends lifespan in insulin deficiency |
| title_short | S100A9 extends lifespan in insulin deficiency |
| title_sort | s100a9 extends lifespan in insulin deficiency |
| url | https://doi.org/10.1038/s41467-019-11498-x |
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