Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters
Objective: To investigate leucocyte mobilization, acid phosphatase and acetylcholinesterase activities during ivermectin therapy for onchocerciasis, to shed light on the mechanism underlying the involvement of the host's immune system. Method: A single oral dose of ivermectin (300 g/kg) was adm...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2008-01-01
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| Series: | International Journal of Medicine and Health Development |
| Subjects: | |
| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2008;volume=13;issue=1;spage=7;epage=12;aulast=Shu;type=0 |
| _version_ | 1811180121540788224 |
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| author | E N Shu E O Eze T Nubila E O Onwujekwe |
| author_facet | E N Shu E O Eze T Nubila E O Onwujekwe |
| author_sort | E N Shu |
| collection | DOAJ |
| description | Objective: To investigate leucocyte mobilization, acid phosphatase and acetylcholinesterase activities during ivermectin therapy for onchocerciasis, to shed light on the mechanism underlying the involvement of the host's immune system.
Method: A single oral dose of ivermectin (300 g/kg) was administered to 78 subjects (42 patients and 36 non-infected) aged between 14 and 40 years. Blood samples were collected from the subjects prior to the administration of the drug at 3, 7 and 14 days post-treatment.
Results: There was no significant increase (P>0.05) in all the blood cell types throughout the study period. Significant increases (P<0.05) were observed in mean neutrophil and eosinophil counts on day 3 and days 0, 3, 7, and 14, respectively in the patients than in the controls. Mean lymphocyte counts were also significantly decreased (p<0.05) on days 3, 7 and 14 in the patients than in the controls. Both acid phosphatase and acetylcholinesterase activities were not significantly altered (p>0.05) throughout the study period.
Conclusion: Killing of microfilariae by radicals generated from neutrophils; and the enhancement of eosinophils against Onchocerca volvulus after treatment with ivermectin is hereby suggested. |
| first_indexed | 2024-04-11T06:45:08Z |
| format | Article |
| id | doaj.art-d8efd248518f4e1a8d1762f76be61704 |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-04-11T06:45:08Z |
| publishDate | 2008-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-d8efd248518f4e1a8d1762f76be617042022-12-22T04:39:22ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952008-01-01131712Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parametersE N ShuE O EzeT NubilaE O OnwujekweObjective: To investigate leucocyte mobilization, acid phosphatase and acetylcholinesterase activities during ivermectin therapy for onchocerciasis, to shed light on the mechanism underlying the involvement of the host's immune system. Method: A single oral dose of ivermectin (300 g/kg) was administered to 78 subjects (42 patients and 36 non-infected) aged between 14 and 40 years. Blood samples were collected from the subjects prior to the administration of the drug at 3, 7 and 14 days post-treatment. Results: There was no significant increase (P>0.05) in all the blood cell types throughout the study period. Significant increases (P<0.05) were observed in mean neutrophil and eosinophil counts on day 3 and days 0, 3, 7, and 14, respectively in the patients than in the controls. Mean lymphocyte counts were also significantly decreased (p<0.05) on days 3, 7 and 14 in the patients than in the controls. Both acid phosphatase and acetylcholinesterase activities were not significantly altered (p>0.05) throughout the study period. Conclusion: Killing of microfilariae by radicals generated from neutrophils; and the enhancement of eosinophils against Onchocerca volvulus after treatment with ivermectin is hereby suggested.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2008;volume=13;issue=1;spage=7;epage=12;aulast=Shu;type=0ivermectinonchocerciasishost cellular immunity |
| spellingShingle | E N Shu E O Eze T Nubila E O Onwujekwe Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters International Journal of Medicine and Health Development ivermectin onchocerciasis host cellular immunity |
| title | Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters |
| title_full | Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters |
| title_fullStr | Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters |
| title_full_unstemmed | Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters |
| title_short | Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters |
| title_sort | ivermectin therapy for onchocerciasis effect on some haematological and biochemical parameters |
| topic | ivermectin onchocerciasis host cellular immunity |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2008;volume=13;issue=1;spage=7;epage=12;aulast=Shu;type=0 |
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