COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA
Objective: To evaluate & compare the mean change in fasting serum total cholesterol and LDL-C levels from baseline, after 12 weeks of oral treatment with oral Rosuvastatin and with Atorvastatin in type 2 diabetic patients with primary hyperlipidemia. Study Design: Cross sectional comparative...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2020-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/5866 |
| _version_ | 1818843072374505472 |
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| author | Safina Shabbir Zill -e- Humayun Muhammad Javad Yousaf Muhammad Adnan Manzar Shabana Mushtaq Maria Yousaf |
| author_facet | Safina Shabbir Zill -e- Humayun Muhammad Javad Yousaf Muhammad Adnan Manzar Shabana Mushtaq Maria Yousaf |
| author_sort | Safina Shabbir |
| collection | DOAJ |
| description | Objective: To evaluate & compare the mean change in fasting serum total cholesterol and LDL-C levels from baseline, after 12 weeks of oral treatment with oral Rosuvastatin and with Atorvastatin in type 2 diabetic patients with primary hyperlipidemia.
Study Design: Cross sectional comparative study.
Place and Duration of Study: The present study was conducted in the Medicine Department, Pakistan Naval Ship, Shifa Hospital, Karachi, from Mar to Sep 2016.
Methodology: The sample was collected by non- probability convenient sampling. The total of 114 DM type 2 patients were randomly divided into two equal groups. Group A was given Rosuvastatin whereas group B was given Atorvastatin orally daily for 12 weeks along with oral treatment for diabetes. After 12 weeks, Fasting Serum Total Cholesterol and Serum LDL-C were estimated, and noted as final levels.
Results: There was greater reduction in terms of mean change in serum total cholesterol levels and low-density lipoprotein – cholesterol (LDL-C) levels with Rosuvastatin as compared to Atorvastatin in type 2 diabetic patients with hyperlipidemia.
Conclusion: Rosuvastatin can significantly improve lipid profile as compared to Atorvastatin in type 2 diabetic patients with hyperlipidemia. |
| first_indexed | 2024-12-19T04:52:03Z |
| format | Article |
| id | doaj.art-d8f0d65f3f354ee8a7f84f9724a06ee8 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-19T04:52:03Z |
| publishDate | 2020-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-d8f0d65f3f354ee8a7f84f9724a06ee82022-12-21T20:35:19ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422020-12-01706167116755866COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIASafina Shabbir0Zill -e- Humayun1Muhammad Javad Yousaf2Muhammad Adnan Manzar3Shabana Mushtaq4Maria Yousaf5Pakistan Naval Ship (PNS) Shifa Hospital, Karachi/National University of Medical Sciences (NUMS) PakistanPakistan Naval Ship (PNS) Shifa Hospital, Karachi/National University of Medical Sciences (NUMS) PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanPak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanPakistan Naval Ship (PNS) Shifa Hospital, Karachi/National University of Medical Sciences (NUMS) PakistanPakistan Naval Ship (PNS) Shifa Hospital, Karachi/National University of Medical Sciences (NUMS) PakistanObjective: To evaluate & compare the mean change in fasting serum total cholesterol and LDL-C levels from baseline, after 12 weeks of oral treatment with oral Rosuvastatin and with Atorvastatin in type 2 diabetic patients with primary hyperlipidemia. Study Design: Cross sectional comparative study. Place and Duration of Study: The present study was conducted in the Medicine Department, Pakistan Naval Ship, Shifa Hospital, Karachi, from Mar to Sep 2016. Methodology: The sample was collected by non- probability convenient sampling. The total of 114 DM type 2 patients were randomly divided into two equal groups. Group A was given Rosuvastatin whereas group B was given Atorvastatin orally daily for 12 weeks along with oral treatment for diabetes. After 12 weeks, Fasting Serum Total Cholesterol and Serum LDL-C were estimated, and noted as final levels. Results: There was greater reduction in terms of mean change in serum total cholesterol levels and low-density lipoprotein – cholesterol (LDL-C) levels with Rosuvastatin as compared to Atorvastatin in type 2 diabetic patients with hyperlipidemia. Conclusion: Rosuvastatin can significantly improve lipid profile as compared to Atorvastatin in type 2 diabetic patients with hyperlipidemia.https://pafmj.org/index.php/PAFMJ/article/view/5866atorvastatindiabetes mellitushyperlipidemiarosuvastatin |
| spellingShingle | Safina Shabbir Zill -e- Humayun Muhammad Javad Yousaf Muhammad Adnan Manzar Shabana Mushtaq Maria Yousaf COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA Pakistan Armed Forces Medical Journal atorvastatin diabetes mellitus hyperlipidemia rosuvastatin |
| title | COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA |
| title_full | COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA |
| title_fullStr | COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA |
| title_full_unstemmed | COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA |
| title_short | COMPARISON OF LIPID LOWERING EFFECTS OF ROSUVASTATIN AND ATORVASTATIN IN TYPE 2 DIABETIC PATIENTS WITH PRIMARY HYPERLIPIDEMIA |
| title_sort | comparison of lipid lowering effects of rosuvastatin and atorvastatin in type 2 diabetic patients with primary hyperlipidemia |
| topic | atorvastatin diabetes mellitus hyperlipidemia rosuvastatin |
| url | https://pafmj.org/index.php/PAFMJ/article/view/5866 |
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