Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study
AbstractPurpose The aim of this study is to investigate the prevention and treatment patterns of deep vein thrombosis (DVT) in critically ill patients and to explore the risk factors for DVT in people from Zhejiang Province, China.Materials and methods This study prospectively enrolled patients admi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.2005822 |
| _version_ | 1827579214355759104 |
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| author | Li Li Jia Zhou Liquan Huang Junhai Zhen Lina Yao Lingen Xu Weimin Zhang Gensheng Zhang Qijiang Chen Bihuan Cheng Shijin Gong Guolong Cai Ronglin Jiang Jing Yan |
| author_facet | Li Li Jia Zhou Liquan Huang Junhai Zhen Lina Yao Lingen Xu Weimin Zhang Gensheng Zhang Qijiang Chen Bihuan Cheng Shijin Gong Guolong Cai Ronglin Jiang Jing Yan |
| author_sort | Li Li |
| collection | DOAJ |
| description | AbstractPurpose The aim of this study is to investigate the prevention and treatment patterns of deep vein thrombosis (DVT) in critically ill patients and to explore the risk factors for DVT in people from Zhejiang Province, China.Materials and methods This study prospectively enrolled patients admitted in intensive care units (ICUs) of 54 hospitals from 09/16/2019 to 01/16/2020. The risk of developing DVT and subsequent prophylaxis was evaluated. The primary outcome was DVT occurrence during ICU hospitalisation. Univariate and multivariate logistic regression were performed to determine the risk factors for DVT.Results A total of 940 patients were included in the study. Among 847 patients who received prophylaxis, 635 (75.0%) patients received physical prophylaxis and 199 (23.5%) patients received drug prophylaxis. Fifty-eight (6.2%) patients were diagnosed with DVT after admission to the ICU, and 36 patients were treated with anticoagulants (all patients received low molecular weight heparin [LMWH]). D-dimer levels (OR = 1.256, 95% CI: 1.132–1.990), basic prophylaxis (OR = 0.092, 95% CI: 0.016–0.536), and physical prophylaxis (OR = 0.159, 95% CI: 0.038–0.674) were independently associated with DVT in ICU patients. The short-term survival was similar between DVT and non-DVT patients.Conclusions DVT prophylaxis is widely performed in ICU patients. Prophylaxis is an independent protective factor for DVT occurrence. The most common treatment of DVT patients is LMWH, although it might increase the rate of bleeding.Key messagesThis is the only multicenter and prospective study of DVT in ICUs in China.d-dimer levels were independently associated with DVT in ICU patients.Prophylaxis was an independent protective factor for DVT occurrence in ICU. |
| first_indexed | 2024-03-08T21:58:29Z |
| format | Article |
| id | doaj.art-d8f163d8ae844a05a538172be567ecc1 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:58:29Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-d8f163d8ae844a05a538172be567ecc12023-12-19T16:46:26ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015312236224710.1080/07853890.2021.2005822Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational studyLi Li0Jia Zhou1Liquan Huang2Junhai Zhen3Lina Yao4Lingen Xu5Weimin Zhang6Gensheng Zhang7Qijiang Chen8Bihuan Cheng9Shijin Gong10Guolong Cai11Ronglin Jiang12Jing Yan13Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Ningbo Yinzhou People’s Hospital, Yinzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Xinchang Hospital of Traditional Chinese Medicine, Xinchang, Zhejiang, ChinaDepartment of Critical Care Medicine, Dongyang People's Hospital, Dongyang, Zhejiang, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Ninghai First Hospital, Ninghai, Zhejiang, ChinaDepartment of Critical Care Medicine, The 2nd School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, Zhejiang, ChinaDepartment of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaAbstractPurpose The aim of this study is to investigate the prevention and treatment patterns of deep vein thrombosis (DVT) in critically ill patients and to explore the risk factors for DVT in people from Zhejiang Province, China.Materials and methods This study prospectively enrolled patients admitted in intensive care units (ICUs) of 54 hospitals from 09/16/2019 to 01/16/2020. The risk of developing DVT and subsequent prophylaxis was evaluated. The primary outcome was DVT occurrence during ICU hospitalisation. Univariate and multivariate logistic regression were performed to determine the risk factors for DVT.Results A total of 940 patients were included in the study. Among 847 patients who received prophylaxis, 635 (75.0%) patients received physical prophylaxis and 199 (23.5%) patients received drug prophylaxis. Fifty-eight (6.2%) patients were diagnosed with DVT after admission to the ICU, and 36 patients were treated with anticoagulants (all patients received low molecular weight heparin [LMWH]). D-dimer levels (OR = 1.256, 95% CI: 1.132–1.990), basic prophylaxis (OR = 0.092, 95% CI: 0.016–0.536), and physical prophylaxis (OR = 0.159, 95% CI: 0.038–0.674) were independently associated with DVT in ICU patients. The short-term survival was similar between DVT and non-DVT patients.Conclusions DVT prophylaxis is widely performed in ICU patients. Prophylaxis is an independent protective factor for DVT occurrence. The most common treatment of DVT patients is LMWH, although it might increase the rate of bleeding.Key messagesThis is the only multicenter and prospective study of DVT in ICUs in China.d-dimer levels were independently associated with DVT in ICU patients.Prophylaxis was an independent protective factor for DVT occurrence in ICU.https://www.tandfonline.com/doi/10.1080/07853890.2021.2005822Deep vein thrombosispreventiontreatmentrisk factorsintensive care unitChina |
| spellingShingle | Li Li Jia Zhou Liquan Huang Junhai Zhen Lina Yao Lingen Xu Weimin Zhang Gensheng Zhang Qijiang Chen Bihuan Cheng Shijin Gong Guolong Cai Ronglin Jiang Jing Yan Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study Annals of Medicine Deep vein thrombosis prevention treatment risk factors intensive care unit China |
| title | Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study |
| title_full | Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study |
| title_fullStr | Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study |
| title_full_unstemmed | Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study |
| title_short | Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study |
| title_sort | prevention treatment and risk factors of deep vein thrombosis in critically ill patients in zhejiang province china a multicenter prospective observational study |
| topic | Deep vein thrombosis prevention treatment risk factors intensive care unit China |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.2005822 |
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