Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy
Abstract Although near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary embolism of post‐phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study...
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201901378 |
| _version_ | 1818020677840535552 |
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| author | Fengrong Zhang Yuehong Liu Jiani Lei Shunhao Wang Xunming Ji Huiyu Liu Qi Yang |
| author_facet | Fengrong Zhang Yuehong Liu Jiani Lei Shunhao Wang Xunming Ji Huiyu Liu Qi Yang |
| author_sort | Fengrong Zhang |
| collection | DOAJ |
| description | Abstract Although near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary embolism of post‐phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study, dual‐modality photothermal/photodynamic thrombolysis is explored using targeting nanoagents with an emphasis on improving biosafety as well as ameliorating the thrombolytic effect. The nanoagents can actively target glycoprotein IIb/IIIa receptors on thrombus to initiate site‐specific thrombolysis by hyperthermia and reactive oxygen species under NIR laser irradiation. In comparison to single photothermal thrombolysis, an 87.9% higher re‐establishment rate of dual‐modality photothermal/photodynamic thrombolysis by one‐time treatment is achieved in a lower limb thrombosis model. The dual‐modality thrombolysis can also avoid re‐embolization after breaking fibrin into tiny fragments. All the results show that this strategy is a safe and validated protocol for thrombolysis, which fits the clinical translational trend of nanomedicine. |
| first_indexed | 2024-04-14T08:08:34Z |
| format | Article |
| id | doaj.art-d8f1893c3b9241f2af17e527b1f56a9d |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-14T08:08:34Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-d8f1893c3b9241f2af17e527b1f56a9d2022-12-22T02:04:40ZengWileyAdvanced Science2198-38442019-09-01617n/an/a10.1002/advs.201901378Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus TherapyFengrong Zhang0Yuehong Liu1Jiani Lei2Shunhao Wang3Xunming Ji4Huiyu Liu5Qi Yang6Department of Radiology Xuanwu Hospital Beijing 100053 P. R. ChinaDepartment of Radiology Xuanwu Hospital Beijing 100053 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 P. R. ChinaDepartment of Neurosurgery Xuanwu Hospital Beijing 100053 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 P. R. ChinaDepartment of Radiology Xuanwu Hospital Beijing 100053 P. R. ChinaAbstract Although near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary embolism of post‐phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study, dual‐modality photothermal/photodynamic thrombolysis is explored using targeting nanoagents with an emphasis on improving biosafety as well as ameliorating the thrombolytic effect. The nanoagents can actively target glycoprotein IIb/IIIa receptors on thrombus to initiate site‐specific thrombolysis by hyperthermia and reactive oxygen species under NIR laser irradiation. In comparison to single photothermal thrombolysis, an 87.9% higher re‐establishment rate of dual‐modality photothermal/photodynamic thrombolysis by one‐time treatment is achieved in a lower limb thrombosis model. The dual‐modality thrombolysis can also avoid re‐embolization after breaking fibrin into tiny fragments. All the results show that this strategy is a safe and validated protocol for thrombolysis, which fits the clinical translational trend of nanomedicine.https://doi.org/10.1002/advs.201901378carbon nanostructuresphotodynamic therapyphotothermal therapythrombus |
| spellingShingle | Fengrong Zhang Yuehong Liu Jiani Lei Shunhao Wang Xunming Ji Huiyu Liu Qi Yang Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy Advanced Science carbon nanostructures photodynamic therapy photothermal therapy thrombus |
| title | Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy |
| title_full | Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy |
| title_fullStr | Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy |
| title_full_unstemmed | Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy |
| title_short | Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy |
| title_sort | metal organic framework derived carbon nanostructures for site specific dual modality photothermal photodynamic thrombus therapy |
| topic | carbon nanostructures photodynamic therapy photothermal therapy thrombus |
| url | https://doi.org/10.1002/advs.201901378 |
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