Defueling the cancer: ATP synthase as an emerging target in cancer therapy

Defueling the cancer: ATP synthase as an emerging target in cancer therapy

Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase (MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing proteins is found during cancer and is linked to a poor prognosis in glioblastoma, ovarian cancer, prostate cancer, breas...

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Bibliographic Details
Main Authors: Ting Wang, Fei Ma, Hai-li Qian
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
mitochondrial ATP synthase
cancer metabolism
mitochondrial metabolism
ATP synthase inhibitor
chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001261

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