Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem)
IntroductionThe endemic form (fogo selvagem—FS) of pemphigus foliaceus is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-1. Despite the array of findings, the role of chemokines and cytokines that dictate the immune response and disease outcome is still...
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00978/full |
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| author | Rodolfo Pessato Timóteo Marcos Vinicius Silva Djalma Alexandre Alves da Silva Jonatas Da Silva Catarino Fernando Henrique Canhoto Alves Virmondes Rodrigues Júnior Ana Maria Roselino Helioswilton Sales-Campos Carlo José Freire Oliveira |
| author_facet | Rodolfo Pessato Timóteo Marcos Vinicius Silva Djalma Alexandre Alves da Silva Jonatas Da Silva Catarino Fernando Henrique Canhoto Alves Virmondes Rodrigues Júnior Ana Maria Roselino Helioswilton Sales-Campos Carlo José Freire Oliveira |
| author_sort | Rodolfo Pessato Timóteo |
| collection | DOAJ |
| description | IntroductionThe endemic form (fogo selvagem—FS) of pemphigus foliaceus is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-1. Despite the array of findings, the role of chemokines and cytokines that dictate the immune response and disease outcome is still poorly investigated.Materials and methodsSerum from 64 patients diagnosed with FS was used to draw and establish the levels of these molecules on this disease and establish the levels of these molecules with the severity of FS, and influence of treatment.ResultsIn comparison to healthy subjects, FS patients, newly diagnosed and still without therapeutic intervention, had higher levels of IL-22 and CXCL-8, and reduced levels of IFN-γ, IL-2, IL-15, and CCL-11. Furthermore, treatment using immunosuppressant drugs augmented the production of IFN-γ, IL-2, CCL-5, and CCL-11 besides reducing the levels of IL-22 and CXCL-10. Immunosuppressive therapy seemed to have long-lasting effects on the production of higher amounts of IFN-γ, IL-2, and CCL-5, besides keeping lowered the levels of IL-22 in remission FS patients.ConclusionTaken together, our findings suggest a putative role of IL-22 in the pathogenesis of FS. Finally, data presented here may contribute for better understanding the immune aspects that control disease outcome. |
| first_indexed | 2024-04-13T00:10:42Z |
| format | Article |
| id | doaj.art-d8f417ec56064fc1826f07f3cbb532e6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T00:10:42Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d8f417ec56064fc1826f07f3cbb532e62022-12-22T03:11:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-08-01810.3389/fimmu.2017.00978286689Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem)Rodolfo Pessato Timóteo0Marcos Vinicius Silva1Djalma Alexandre Alves da Silva2Jonatas Da Silva Catarino3Fernando Henrique Canhoto Alves4Virmondes Rodrigues Júnior5Ana Maria Roselino6Helioswilton Sales-Campos7Carlo José Freire Oliveira8Laboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilDivision of Dermatology, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilDivision of Dermatology, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilLaboratory of Immunology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, BrazilIntroductionThe endemic form (fogo selvagem—FS) of pemphigus foliaceus is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-1. Despite the array of findings, the role of chemokines and cytokines that dictate the immune response and disease outcome is still poorly investigated.Materials and methodsSerum from 64 patients diagnosed with FS was used to draw and establish the levels of these molecules on this disease and establish the levels of these molecules with the severity of FS, and influence of treatment.ResultsIn comparison to healthy subjects, FS patients, newly diagnosed and still without therapeutic intervention, had higher levels of IL-22 and CXCL-8, and reduced levels of IFN-γ, IL-2, IL-15, and CCL-11. Furthermore, treatment using immunosuppressant drugs augmented the production of IFN-γ, IL-2, CCL-5, and CCL-11 besides reducing the levels of IL-22 and CXCL-10. Immunosuppressive therapy seemed to have long-lasting effects on the production of higher amounts of IFN-γ, IL-2, and CCL-5, besides keeping lowered the levels of IL-22 in remission FS patients.ConclusionTaken together, our findings suggest a putative role of IL-22 in the pathogenesis of FS. Finally, data presented here may contribute for better understanding the immune aspects that control disease outcome.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00978/fullpemphigus foliaceusfogo selvagemIL-22cytokineschemokinespathogenesis |
| spellingShingle | Rodolfo Pessato Timóteo Marcos Vinicius Silva Djalma Alexandre Alves da Silva Jonatas Da Silva Catarino Fernando Henrique Canhoto Alves Virmondes Rodrigues Júnior Ana Maria Roselino Helioswilton Sales-Campos Carlo José Freire Oliveira Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) Frontiers in Immunology pemphigus foliaceus fogo selvagem IL-22 cytokines chemokines pathogenesis |
| title | Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) |
| title_full | Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) |
| title_fullStr | Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) |
| title_full_unstemmed | Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) |
| title_short | Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) |
| title_sort | cytokine and chemokines alterations in the endemic form of pemphigus foliaceus fogo selvagem |
| topic | pemphigus foliaceus fogo selvagem IL-22 cytokines chemokines pathogenesis |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00978/full |
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