Insights into Regulators of p53 Acetylation
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the selectivity of target genes. Acetylation plays...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3825 |
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| author | Mai Nagasaka Chiharu Miyajima Hiromasa Aoki Mineyoshi Aoyama Daisuke Morishita Yasumichi Inoue Hidetoshi Hayashi |
| author_facet | Mai Nagasaka Chiharu Miyajima Hiromasa Aoki Mineyoshi Aoyama Daisuke Morishita Yasumichi Inoue Hidetoshi Hayashi |
| author_sort | Mai Nagasaka |
| collection | DOAJ |
| description | The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the selectivity of target genes. Acetylation plays an essential role in cell fate determination through the activation of p53. Although the acetylation of p53 has been examined, the underlying regulatory mechanisms remain unclear and, thus, have attracted the interest of researchers. We herein discuss the role of acetylation in the p53 pathway, with a focus on p53 acetyltransferases and deacetylases. We also review recent findings on the regulators of these enzymes to understand the mode of p53 acetylation from a broader perspective. |
| first_indexed | 2024-03-09T17:51:46Z |
| format | Article |
| id | doaj.art-d8f6e75a10914b80b6059f190ae35569 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:51:46Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d8f6e75a10914b80b6059f190ae355692023-11-24T10:44:24ZengMDPI AGCells2073-44092022-11-011123382510.3390/cells11233825Insights into Regulators of p53 AcetylationMai Nagasaka0Chiharu Miyajima1Hiromasa Aoki2Mineyoshi Aoyama3Daisuke Morishita4Yasumichi Inoue5Hidetoshi Hayashi6Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanThe tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the selectivity of target genes. Acetylation plays an essential role in cell fate determination through the activation of p53. Although the acetylation of p53 has been examined, the underlying regulatory mechanisms remain unclear and, thus, have attracted the interest of researchers. We herein discuss the role of acetylation in the p53 pathway, with a focus on p53 acetyltransferases and deacetylases. We also review recent findings on the regulators of these enzymes to understand the mode of p53 acetylation from a broader perspective.https://www.mdpi.com/2073-4409/11/23/3825p53post-translational modificationacetylationdeacetylation |
| spellingShingle | Mai Nagasaka Chiharu Miyajima Hiromasa Aoki Mineyoshi Aoyama Daisuke Morishita Yasumichi Inoue Hidetoshi Hayashi Insights into Regulators of p53 Acetylation Cells p53 post-translational modification acetylation deacetylation |
| title | Insights into Regulators of p53 Acetylation |
| title_full | Insights into Regulators of p53 Acetylation |
| title_fullStr | Insights into Regulators of p53 Acetylation |
| title_full_unstemmed | Insights into Regulators of p53 Acetylation |
| title_short | Insights into Regulators of p53 Acetylation |
| title_sort | insights into regulators of p53 acetylation |
| topic | p53 post-translational modification acetylation deacetylation |
| url | https://www.mdpi.com/2073-4409/11/23/3825 |
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