Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report
Abstract Background Non-tuberculous mycobacteria (NTM) are environmental organisms that are increasingly contributing to human infections. Mycobacterium immunogenum, a variant of NTM discovered in 2001, is a rapidly growing mycobacterium that exhibits multidrug resistance. Reports of infections caus...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-09249-5 |
| _version_ | 1797209508203724800 |
|---|---|
| author | Tomohide Okinaka Kenjiro Fujimura Yuka Hamasaki Yuichi Hasegawa Takashi Matono |
| author_facet | Tomohide Okinaka Kenjiro Fujimura Yuka Hamasaki Yuichi Hasegawa Takashi Matono |
| author_sort | Tomohide Okinaka |
| collection | DOAJ |
| description | Abstract Background Non-tuberculous mycobacteria (NTM) are environmental organisms that are increasingly contributing to human infections. Mycobacterium immunogenum, a variant of NTM discovered in 2001, is a rapidly growing mycobacterium that exhibits multidrug resistance. Reports of infections caused by this organism, particularly tenosynovitis in the musculoskeletal system, are limited. Case presentation A 71-year-old female with vesicular pemphigus, undergoing immunosuppressive therapy, presented with a progressively enlarging tumour on the dorsum of her right hand, along with erythematous papules that extended across her right forearm. The specimens of skin tissues and blood cultures revealed the presence of M. immunogenum. Magnetic resonance imaging evaluation led to the diagnosis of pyogenic extensor tenosynovitis. A multidrug regimen, comprising amikacin and clarithromycin, was initiated, followed by synovectomy. The patient underwent a course of 180 days of antimicrobial therapy and demonstrated no signs of disease recurrence one year after treatment completion. Conclusion Early diagnosis and surgical intervention are crucial to prevent the adverse prognostic implications of pyogenic extensor tenosynovitis caused by M. immunogenum. Effective management requires precise microbial identification and susceptibility testing, necessitating collaborative engagement with microbiological laboratories. |
| first_indexed | 2024-04-24T09:55:49Z |
| format | Article |
| id | doaj.art-d8f73a1564f24471badfddf9ae54ec7d |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-24T09:55:49Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-d8f73a1564f24471badfddf9ae54ec7d2024-04-14T11:08:52ZengBMCBMC Infectious Diseases1471-23342024-04-012411610.1186/s12879-024-09249-5Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case reportTomohide Okinaka0Kenjiro Fujimura1Yuka Hamasaki2Yuichi Hasegawa3Takashi Matono4Department of Infectious Diseases, Aso Iizuka HospitalDepartment of Orthopedic Surgery, Aso Iizuka HospitalDepartment of Dermatology, Inatsuki HospitalDepartment of Infectious Diseases, Aso Iizuka HospitalDepartment of Infectious Diseases, Aso Iizuka HospitalAbstract Background Non-tuberculous mycobacteria (NTM) are environmental organisms that are increasingly contributing to human infections. Mycobacterium immunogenum, a variant of NTM discovered in 2001, is a rapidly growing mycobacterium that exhibits multidrug resistance. Reports of infections caused by this organism, particularly tenosynovitis in the musculoskeletal system, are limited. Case presentation A 71-year-old female with vesicular pemphigus, undergoing immunosuppressive therapy, presented with a progressively enlarging tumour on the dorsum of her right hand, along with erythematous papules that extended across her right forearm. The specimens of skin tissues and blood cultures revealed the presence of M. immunogenum. Magnetic resonance imaging evaluation led to the diagnosis of pyogenic extensor tenosynovitis. A multidrug regimen, comprising amikacin and clarithromycin, was initiated, followed by synovectomy. The patient underwent a course of 180 days of antimicrobial therapy and demonstrated no signs of disease recurrence one year after treatment completion. Conclusion Early diagnosis and surgical intervention are crucial to prevent the adverse prognostic implications of pyogenic extensor tenosynovitis caused by M. immunogenum. Effective management requires precise microbial identification and susceptibility testing, necessitating collaborative engagement with microbiological laboratories.https://doi.org/10.1186/s12879-024-09249-5Mycobacterium immunogenumPyogenic extensor tenosynovitisNontuberculous mycobacteriumRapidly growing mycobacteria |
| spellingShingle | Tomohide Okinaka Kenjiro Fujimura Yuka Hamasaki Yuichi Hasegawa Takashi Matono Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report BMC Infectious Diseases Mycobacterium immunogenum Pyogenic extensor tenosynovitis Nontuberculous mycobacterium Rapidly growing mycobacteria |
| title | Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report |
| title_full | Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report |
| title_fullStr | Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report |
| title_full_unstemmed | Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report |
| title_short | Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report |
| title_sort | significance of early diagnosis and surgical management in treating mycobacterium immunogenum related pyogenic extensor tenosynovitis a case report |
| topic | Mycobacterium immunogenum Pyogenic extensor tenosynovitis Nontuberculous mycobacterium Rapidly growing mycobacteria |
| url | https://doi.org/10.1186/s12879-024-09249-5 |
| work_keys_str_mv | AT tomohideokinaka significanceofearlydiagnosisandsurgicalmanagementintreatingmycobacteriumimmunogenumrelatedpyogenicextensortenosynovitisacasereport AT kenjirofujimura significanceofearlydiagnosisandsurgicalmanagementintreatingmycobacteriumimmunogenumrelatedpyogenicextensortenosynovitisacasereport AT yukahamasaki significanceofearlydiagnosisandsurgicalmanagementintreatingmycobacteriumimmunogenumrelatedpyogenicextensortenosynovitisacasereport AT yuichihasegawa significanceofearlydiagnosisandsurgicalmanagementintreatingmycobacteriumimmunogenumrelatedpyogenicextensortenosynovitisacasereport AT takashimatono significanceofearlydiagnosisandsurgicalmanagementintreatingmycobacteriumimmunogenumrelatedpyogenicextensortenosynovitisacasereport |