Extracellular vesicles in parasitic diseases
Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-12-01
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| Series: | Journal of Extracellular Vesicles |
| Subjects: | |
| Online Access: | http://www.journalofextracellularvesicles.net/index.php/jev/article/view/25040/pdf_3 |
| _version_ | 1819001352749056000 |
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| author | Antonio Marcilla Lorena Martin-Jaular Maria Trelis Armando de Menezes-Neto Antonio Osuna Dolores Bernal Carmen Fernandez-Becerra Igor C. Almeida Hernando A. del Portillo |
| author_facet | Antonio Marcilla Lorena Martin-Jaular Maria Trelis Armando de Menezes-Neto Antonio Osuna Dolores Bernal Carmen Fernandez-Becerra Igor C. Almeida Hernando A. del Portillo |
| author_sort | Antonio Marcilla |
| collection | DOAJ |
| description | Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases, acting both in parasite–parasite inter-communication as well as in parasite–host interactions. EVs participate in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this review, we provide the most relevant findings of the involvement of EVs in intercellular communication, modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and therapeutic agents in some of the major human parasitic pathogens. |
| first_indexed | 2024-12-20T22:47:51Z |
| format | Article |
| id | doaj.art-d8f93240a7104bdaaca06ae66dc734fd |
| institution | Directory Open Access Journal |
| issn | 2001-3078 |
| language | English |
| last_indexed | 2024-12-20T22:47:51Z |
| publishDate | 2014-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Vesicles |
| spelling | doaj.art-d8f93240a7104bdaaca06ae66dc734fd2022-12-21T19:24:20ZengWileyJournal of Extracellular Vesicles2001-30782014-12-013011510.3402/jev.v3.2504025040Extracellular vesicles in parasitic diseasesAntonio Marcilla0Lorena Martin-Jaular1Maria Trelis2Armando de Menezes-Neto3Antonio Osuna4Dolores Bernal5Carmen Fernandez-Becerra6Igor C. Almeida7Hernando A. del Portillo8 Departament de Biologia Cel.lular i Parasitologia, Universitat de València, Valencia, Spain ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain Departament de Biologia Cel.lular i Parasitologia, Universitat de València, Valencia, Spain ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain Institute of Biotechnology, Biochemistry and Molecular Parasitology, University of Granada, Granada, Spain Departament de Bioquímica i Biologia Molecular, Universitat de València, Valencia, Spain ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso (UTEP), El Paso, TX, USA ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, SpainParasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases, acting both in parasite–parasite inter-communication as well as in parasite–host interactions. EVs participate in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this review, we provide the most relevant findings of the involvement of EVs in intercellular communication, modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and therapeutic agents in some of the major human parasitic pathogens.http://www.journalofextracellularvesicles.net/index.php/jev/article/view/25040/pdf_3extracellular vesiclesmicrovesiclesexosomesparasitesprotozoahelminths |
| spellingShingle | Antonio Marcilla Lorena Martin-Jaular Maria Trelis Armando de Menezes-Neto Antonio Osuna Dolores Bernal Carmen Fernandez-Becerra Igor C. Almeida Hernando A. del Portillo Extracellular vesicles in parasitic diseases Journal of Extracellular Vesicles extracellular vesicles microvesicles exosomes parasites protozoa helminths |
| title | Extracellular vesicles in parasitic diseases |
| title_full | Extracellular vesicles in parasitic diseases |
| title_fullStr | Extracellular vesicles in parasitic diseases |
| title_full_unstemmed | Extracellular vesicles in parasitic diseases |
| title_short | Extracellular vesicles in parasitic diseases |
| title_sort | extracellular vesicles in parasitic diseases |
| topic | extracellular vesicles microvesicles exosomes parasites protozoa helminths |
| url | http://www.journalofextracellularvesicles.net/index.php/jev/article/view/25040/pdf_3 |
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