The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer
Leptomeningeal metastasis (LM) is a serious complication of advanced non–small cell lung cancer (NSCLC), and the incidence of LM has been increasing yearly in recent times. There is no consensus on the best treatment modality for LM, which underscores a difficult problem in the management of advance...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-10-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.1177/11795549231205206 |
| _version_ | 1797644718054572032 |
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| author | Yuhua Zhao Limeng Yu Lili Wang Yingxi Wu Haiyang Chen Qiming Wang Yufeng Wu |
| author_facet | Yuhua Zhao Limeng Yu Lili Wang Yingxi Wu Haiyang Chen Qiming Wang Yufeng Wu |
| author_sort | Yuhua Zhao |
| collection | DOAJ |
| description | Leptomeningeal metastasis (LM) is a serious complication of advanced non–small cell lung cancer (NSCLC), and the incidence of LM has been increasing yearly in recent times. There is no consensus on the best treatment modality for LM, which underscores a difficult problem in the management of advanced NSCLC patients. The existing treatments include molecular targeted therapy, systemic chemotherapy, local radiotherapy, antivascular tumor therapy, intrathecal chemotherapy, and immunotherapy, but their efficacy is not satisfactory. In this article, we briefly describe the clinical manifestations, diagnosis, and treatment of NSCLC-LM and discuss progress regarding evaluation of the efficacy of LM treatment to better provide a necessary reference for clinical practice and clinical trial evaluation. |
| first_indexed | 2024-03-11T14:34:42Z |
| format | Article |
| id | doaj.art-d8f96eeda5b94c1ebd1d85489b876fb4 |
| institution | Directory Open Access Journal |
| issn | 1179-5549 |
| language | English |
| last_indexed | 2024-03-11T14:34:42Z |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj.art-d8f96eeda5b94c1ebd1d85489b876fb42023-10-31T05:34:01ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492023-10-011710.1177/11795549231205206The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung CancerYuhua ZhaoLimeng YuLili WangYingxi WuHaiyang ChenQiming WangYufeng WuLeptomeningeal metastasis (LM) is a serious complication of advanced non–small cell lung cancer (NSCLC), and the incidence of LM has been increasing yearly in recent times. There is no consensus on the best treatment modality for LM, which underscores a difficult problem in the management of advanced NSCLC patients. The existing treatments include molecular targeted therapy, systemic chemotherapy, local radiotherapy, antivascular tumor therapy, intrathecal chemotherapy, and immunotherapy, but their efficacy is not satisfactory. In this article, we briefly describe the clinical manifestations, diagnosis, and treatment of NSCLC-LM and discuss progress regarding evaluation of the efficacy of LM treatment to better provide a necessary reference for clinical practice and clinical trial evaluation.https://doi.org/10.1177/11795549231205206 |
| spellingShingle | Yuhua Zhao Limeng Yu Lili Wang Yingxi Wu Haiyang Chen Qiming Wang Yufeng Wu The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer Clinical Medicine Insights: Oncology |
| title | The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer |
| title_full | The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer |
| title_fullStr | The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer |
| title_full_unstemmed | The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer |
| title_short | The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer |
| title_sort | riddle of the sphinx progress in leptomeningeal metastasis of non small cell lung cancer |
| url | https://doi.org/10.1177/11795549231205206 |
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