Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart
Pisonia alba Span. is a small tree with single oval leaves and belongs to the Nyctaginaceae family. Subacute toxicity of the crude extract of this plant was investigated. Doses of 0.5, 1 and 2 g/kg of the crude extract were tested in rats via oral feeding administration in a once daily regimen for 4...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2003-05-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://www.sjst.psu.ac.th/journal/25-4-pdf/11subacute%20toxicity.pdf |
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| author | Somsamorn Chittrakarn Supaporn Prasettho Uraporn Vongvatcharanon |
| author_facet | Somsamorn Chittrakarn Supaporn Prasettho Uraporn Vongvatcharanon |
| author_sort | Somsamorn Chittrakarn |
| collection | DOAJ |
| description | Pisonia alba Span. is a small tree with single oval leaves and belongs to the Nyctaginaceae family. Subacute toxicity of the crude extract of this plant was investigated. Doses of 0.5, 1 and 2 g/kg of the crude extract were tested in rats via oral feeding administration in a once daily regimen for 45 days. The average body weight of those rats receiving the crude extract was not significantly elevated in comparison with that of the control group. Moreover, the observed behavior of those rats was not different from that of the control group. Histopathological study of the rat liver, however, showed that the average density of necrotic hepatocytes in the treated group was 1.63±0.47 and 1.21±0.33 cell/mm2 with the doses of 1 and 2 g/kg of the crude extract, respectively. These values were significantly lower than those of the control group (2.04±0.68 cell/ mm2) (p<0.05). A histopathological study of the heart of rats receiving the crude extract of P. alba at doses of 0.5, 1 and 2 g/kg showed that, at all doses, the volume of wall of each chamber was not significantly different from that of the control group. In addition, it did not cause cardiomyocyte injury. The results obtained suggest that the crude extract of P. alba leaves at the dose up to 2 g/kg has no toxic effect on the liver andheart of rats. |
| first_indexed | 2024-12-21T16:43:55Z |
| format | Article |
| id | doaj.art-d8f9cefd87904b708f19972814d7f1c4 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-12-21T16:43:55Z |
| publishDate | 2003-05-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-d8f9cefd87904b708f19972814d7f1c42022-12-21T18:57:02ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952003-05-01254515524Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heartSomsamorn ChittrakarnSupaporn PrasetthoUraporn VongvatcharanonPisonia alba Span. is a small tree with single oval leaves and belongs to the Nyctaginaceae family. Subacute toxicity of the crude extract of this plant was investigated. Doses of 0.5, 1 and 2 g/kg of the crude extract were tested in rats via oral feeding administration in a once daily regimen for 45 days. The average body weight of those rats receiving the crude extract was not significantly elevated in comparison with that of the control group. Moreover, the observed behavior of those rats was not different from that of the control group. Histopathological study of the rat liver, however, showed that the average density of necrotic hepatocytes in the treated group was 1.63±0.47 and 1.21±0.33 cell/mm2 with the doses of 1 and 2 g/kg of the crude extract, respectively. These values were significantly lower than those of the control group (2.04±0.68 cell/ mm2) (p<0.05). A histopathological study of the heart of rats receiving the crude extract of P. alba at doses of 0.5, 1 and 2 g/kg showed that, at all doses, the volume of wall of each chamber was not significantly different from that of the control group. In addition, it did not cause cardiomyocyte injury. The results obtained suggest that the crude extract of P. alba leaves at the dose up to 2 g/kg has no toxic effect on the liver andheart of rats.http://www.sjst.psu.ac.th/journal/25-4-pdf/11subacute%20toxicity.pdfSaengchansubacute toxicityPisonia alba Span.histopathological study |
| spellingShingle | Somsamorn Chittrakarn Supaporn Prasettho Uraporn Vongvatcharanon Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart Songklanakarin Journal of Science and Technology (SJST) Saengchan subacute toxicity Pisonia alba Span. histopathological study |
| title | Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart |
| title_full | Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart |
| title_fullStr | Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart |
| title_full_unstemmed | Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart |
| title_short | Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart |
| title_sort | subacute toxicity study of crude extract of pisonia alba span leaves on rat liver and heart |
| topic | Saengchan subacute toxicity Pisonia alba Span. histopathological study |
| url | http://www.sjst.psu.ac.th/journal/25-4-pdf/11subacute%20toxicity.pdf |
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